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Cell (Play) - Astrophysics Data System

Summarized by Plex Scholar
Last Updated: 10 April 2022

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Malfunction of airway basal stem cells plays a crucial role in pathophysiology of tracheobronchopathia osteoplastica

Tracheobronchochondroplastica, under-detected tracheobronchopulmonary disease of unknown etiology and a lack of specific treatment, is reported here by a multifaceted research on airway epithelial stem cells in Tracheobronchochondroplastica. We show a role for airway basal cells in TO evolution by both transcriptional and epigenetic profiling, which aids in both epithelial metaplasia and mesenchymal osteo-chondrogenesis by extracellular signaling and matrix remodeling, contributing to both epithelial and mesenchymal osteo-chondrogenesis.

Source link: https://ui.adsabs.harvard.edu/abs/2022NatCo..13.1309H/abstract

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions