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Malfunction of airway basal stem cells plays a crucial role in pathophysiology of tracheobronchopathia osteoplastica

Tracheobronchochondroplastica, under-detected tracheobronchopulmonary disease of unknown etiology and a lack of specific treatment, is reported here by a multifaceted research on airway epithelial stem cells in Tracheobronchochondroplastica. We show a role for airway basal cells in TO evolution by both transcriptional and epigenetic profiling, which aids in both epithelial metaplasia and mesenchymal osteo-chondrogenesis by extracellular signaling and matrix remodeling, contributing to both epithelial and mesenchymal osteo-chondrogenesis.

Source link: https://ui.adsabs.harvard.edu/abs/2022NatCo..13.1309H/abstract

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