Cell (Play) - Astrophysics Data System

Malfunction of airway basal stem cells plays a crucial role in pathophysiology of tracheobronchopathia osteoplastica

In Tracheobronchochondroplastica, under-diagnosed tracheobronchial disorder of unknown etiology and lack of specific treatment, we present a multifaceted research on airway epithelial stem cells. We show a role of airway basal cells in TO evolution by functioning as a source of inflammatory and TGFu03b2-BMP signals by extracellular signaling and matrix remodeling, both epithelial metaplasia and mesenchymal osteogenesis.

Source link: https://ui.adsabs.harvard.edu/abs/2022NatCo..13.1309H/abstract

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