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Cell (Novel) - Europe PMC

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Last Updated: 10 September 2022

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A novel tumor-homing TRAIL variant eradicates tumor xenografts of refractory colorectal cancer cells in combination with tumor cell-targeted photodynamic therapy.

Tumor necrosis factor-inducing ligand is a novel device for CRC therapy due to its robust and selective apoptosis induction in certain CRC cells with MDR. In CRC cells, RGR-TRAIL showed greater cell binding and cytotoxicity in comparison to TRAIL. In addition, RGR-TRAIL's actions in mice carrying CRC tumor xenografts resulted in significant tumor uptake and growth suppression. TRAIL, on the other hand, only showed modest tumor growth inhibition under the same conditions, indicating that RGR fusion had a significant effect on DR-overexpressing CRC cells by increasing tumor homing. However, RGR fusion did not significantly raise the antitumor activity of TRAIL in HT29 cells with low DR levels in HT29 cells.

Source link: https://europepmc.org/article/MED/35635308


Novel role of Dipterocarpus tuberculatus as a stimulator of focal cell adhesion through the regulation of MLC2/FAK/Akt signaling pathway.

After a D. tuberculatus treatment with methanol extracts, we were able to investigate a novel function of Dipterocarpus tuberculatus on focal cell adhesion stimulation in NHDF cells and a calvarial defect rat model. The findings of the present research show new evidence that MED can cause focal cell adhesion in NHDF cells and a calvarial defect rat model.

Source link: https://europepmc.org/article/MED/35615953


Red cell distribution width: a novel predictive biomarker for stroke risk after transient ischaemic attack.

The aim of this research was to see whether subsequent strokes in TIA patients can be predicted by red blood cell distribution width. Within 7 days after TIA, the patients were divided into three groups: 103 TIA patients, 206 ischaemic stroke patients, and 51 patients with haemorrhagic stroke. Patients with IS and HS after TIA were substantially higher than those with TIA. RDW's diagnostic power in the differentiation of patients with IS after TIA was higher compared to ABCD 2 scores.

Source link: https://europepmc.org/article/MED/35471128


Efficacy of a novel large-cell Niti-S stent with a slim delivery system for hilar biliary obstruction: a preliminary study.

About the goal The large-cell Niti-Stent is suitable for multiple stenting procedures in patients with malignant hilar biliary obstruction. In this report, we wanted to investigate the safety of this USEMS slim delivery system in MHBO patients. Outcomes related to USEMS placement, the medical course, and a period of persistent biliary blockage were determined in MHBO patients who received multiple USEMSs with the Niti-S large-cell SR slim delivery system were analyzed. In the remaining patients, the new slim delivery system was installed as the first stent in ten patients and as an additional stent. Although difficult cases were included in this analysis, stent-in-stent placement with the Niti-S large-cell SR slim delivery device was effective in treating MHBO patients. In addition, this novel stent may be the first choice for MHBO patients, according to KEY MESSAGE The first choice for MHBO patients is difficult. In addition, reintervention or multistenting for MHBO patients with a history of abdominal surgery is becoming more difficult. The Niti-S large-cell SR slim delivery USEMS is a good starting point, because the delivery system is thin and suitable for a 0. 025 guidewire. According to this, the Niti-S large-cell SR slim delivery stent is expected to have a high radial strength and can be used in patients undergoing upper intestinal transplantation. Patients with reintervention or a recent history of upper gastrointestinal reconstruction were found to be 100%, according to this report.

Source link: https://europepmc.org/article/MED/35412414


Functional proteomics of patient derived head and neck squamous cell carcinoma cells reveal novel applications of trametinib.

In 20 head and neck squamous cell carcinoma patients' tumor-derived cell cultures, we report a difference in mitogen-activated protein kinase inhibitor trametinib in this research. Both in vitro and in vivo, the combination of trametinib and AXL/MET/VEGFR inhibitor glesatinib demonstrated initial effectiveness both in vitro and in vivo. Sensitivity was established in vivo in a patient-derived xenograft model in which trametinib alone caused tumour volume reductions of up to 72%. As a neoadjuvant to surgical procedures, Intrinsic-targeted options have the ability to address the paucity of medical treatment options for HNSCC cancer patients, improve response to extrinsic therapeutic agents, and/or reduce morbidity.

Source link: https://europepmc.org/article/MED/35343367


A novel lncRNA BF368575 promotes cell proliferation in hepatocellular carcinoma via PI3K/AKT/mTOR signaling pathway

Methods The expression of lncRNA-BF368575 in HCC tissues and cell lines was tested by reverse transcription-quantitative polymerase chain reaction. The expression of lncRNA-BF368575 was determined by in situ hybridization of 89 paired HCC and para-cancerous tissues in a tissue chip containing 89 paired HCC and para-cancerous tissues. Cell viability and colony-forming capability were determined by cell counting kit-8 assay and colony assay assay. Tumor growth in vivo was found using the xenograft technique. Conclusions The results showed that lncRNA-BF368575 was elevated in most HCC tissues and cell lines, according to the authors. Downregulation of lncRNA-BF368575 in vitro and in vivo experiments showed cell proliferation and colony-forming activity, but overexpression of lncRNA-BF368575 leads to an opposite result. Conclusion Our research shows that lncRNA-BF368575 promotes HCC formation and expansion both in vitro and vivo by triggering the PI3K/AKT/mTOR signaling pathway, which means that our results may also be a potential target for HCC treatment.

Source link: https://europepmc.org/article/PPR/PPR541711


Novel tri-specific tribodies induce strong T cell activation and anti-tumor effects in vitro and in vivo.

Background Immunotherapy based on Bi-specific T Cell Engagers represents one of the most effective ways to treat cancers that are resistant to conventional therapies. TCE are antibody-like proteins that bind one arm to a Tumor Associated Antigen on cancer cells and the other to a T-cell complex, resulting in TCR-independent immune synapse and circumvent Human Leucocyte Antigen restriction. Conclusions Compared to the parental Tb535H bi-specific T cell engager attacking 5T4, the novel 53X tribodies retained similar binding characteristics, but demonstrated higher anti-tumor potency due to the incorporation of the checkpoint inhibitory moiety.

Source link: https://europepmc.org/article/MED/36071464


SCDD: a novel single-cell RNA-seq imputation method with diffusion and denoising.

To investigate cell fates and cell differences, single-cell sequencing techniques are widely used. Since dropout events can stifle the investigation, several imputation techniques for single-cell RNA-seq results have appeared in previous attempts. The initial imputation at first was performed by a direct imputation technique that used the expression of similar cells for potential dropout centers. After the diffusion, a joint model of graph convolutional neural network and contractive autoencoder is created to produce superposition states of similar cells, from which we recover the original states and eliminate the noise created by diffusion.

Source link: https://europepmc.org/article/MED/36070866


Novel antigen presenting cell imparts Treg-dependent tolerance to gut microbiota.

Within the thymus, medullary thymic epithelial cells expressing AutoImmune Regulator, Aire, play a significant role in self-tolerance by deletion of autoreactive T cells and promotion of thymic regulatory T cell proliferation. 1-4 Interestingly, the cell types responsible for the production of peripheral Treg cells are unknown within weeks of birth, following exposure to dietary and commensal microbiota derived antigens 5-8. While TC I and III displayed the definitive mTEC nuclear factor Aire, including the TGF-u03b2 activating integrin, u03b28, a TIME III exploded Thyroid cell factor aire. In comparison, MHCII expression by ROR3b3t+ group 3 innate lymphoid cells and classical DCs was neither relevant nor necessary for pTreg generation, while involving TC IV as the tolerogenic ROR3t+ APC with an important early life function.

Source link: https://europepmc.org/article/MED/36070798


Clinical usefulness of a novel classification of T cell distribution patterns in the tumor microenvironment of follicular lymphoma to detect transformation.

Infiltrating immune cells in the tumor microenvironment are believed to have influenced the clinical course of follicular lymphoma. This research was a retrospectively cohort investigation into the correlation between the pathological distribution pattern of T cells in the tumor microenvironment and the clinical course of FL. One hundred twenty-eight patients with FL who were hospitalized at the University of Tokyo Hospital from January 2008 to January 2017 were assessed. In the adjusted model, there was a substantial difference in the risk of transition between the EFM and EFD around the extra-follicle region. Also, cases with IFF and EFM were at a significant risk of transformation compared to those with other T cell distribution patterns. We developed a new classification of CD3-positive T cell distribution patterns around the follicle lesions in Florida, which also established its clinical significance.

Source link: https://europepmc.org/article/MED/36069932

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions