Cell (Novel) - DOAJ

Pathways of Glucagon Secretion and Trafficking in the Pancreatic Alpha Cell: Novel Pathways, Proteins, and Targets for Hyperglucagonemia

Both Type 1 and Type 2 diabetes may cause hyperglucagonemia due to defective alpha cell secretory responses to glucose and paracrine effectors. In this study, we explore alpha cell biology as potential causes for diabetes alpha cell dysfunction, intrinsic and paracrine regulation of glucagon secretion, mistination of granule dynamics, and changes in intracellular trafficking.

Source link: https://doi.org/10.3389/fendo.2021.726368

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