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Cell (Biology) - Europe PMC

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Last Updated: 10 September 2022

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Anterior gradient proteins in gastrointestinal cancers: from cell biology to pathophysiology.

The majority of the digestive tract's organs contain obscure epithelia that must be used by specific molecular machines to function. These anterior gradient proteins, which make up AGR1, AGR2, and AGR3, are related to the protein disulfide isomerase family and play a role in secretory and transmembrane protein biosynthesis in the endoplasmic reticulum. AGR2 overexpression has recently been attributed to a poor prognosis in digestive cancers. AGR2 is also involved in epithelial homeostasis. The deletion of mice in mice results in severe diffuse gut inflammation, while in chronic bowel diseases, the cellular microenvironment's mystery, AGR2's extracellular milieu, participates in the reshaping of the cellular microenvironment. We introduce the AGR family proteins in digestive disorders, their manifestation in the healthy digestive tract, and digestive oncology in this report. We discuss the potential diagnostic and therapeutic implications of AGR proteins' biology at last.

Source link: https://europepmc.org/article/MED/36068336


Role of the SEC62 gene in dermato-oncology - impact on tumor cell biology, prognostication, and personalized therapy management.

Sec62 protein, which is involved in the post-translational transport of secretory and membrane-bound proteins in eukaryotic cells, controls intracellular calcium homeostasis by direct contact with the Sec61 channel, and is a key contributor to ER stress in the context of recovER-phagy. SEC62 expression in atypical fibroxanthomas and malignant melanomas has already been reported, and a correlation of SEC62 expression with various clinical and pathological characteristics has been observed.

Source link: https://europepmc.org/article/MED/36067526


Quantitative proteomics and lipidomics of TFG-deficient B cells provide insights into mechanisms of autophagic flux and plasma cell biology

TFG production of B cell differentiation into plasma cells is up-regulated during B cell differentiation into plasma cells and supports CH12 B cells' survival. We hypothesized that quantitative proteomics testing of CH12 tfg KO B cells with intact or blocked autophagy-lysosome flux could reveal the causes of TFG-dependent autophagy, plasma cell biology, and B cell survival. BCL10 was decreased within the B cell-relevant protein pool, while JCHAIN was increased in CH12 tfg B cells. The amount of CL was increased in CH12 tfg B cells, which was also a precursor to Cardiolipin. TFG is a transcription factor in B cell activation and plasma cell biology, as well as BCL10 and JCHAIN, as well as in lipid homeostasis, mitochondria, and metabolism.

Source link: https://europepmc.org/article/PPR/PPR539970


Molecular Biology and Therapeutic Perspectives for K-Ras Mutant Non-Small Cell Lung Cancers.

The most common alterations have been found in the Kirsten rat sarcoma viral oncogene homolog gene, accounting for approximately 30% of cases in Caucasian patients. According to First, the most recent findings show that KRAS-mutant lung AC patients have lower overall survival. The present review will focus on the physiological aspects of KRAS mutations in NSCLC, including mechanisms of resistance. Also, the interactions between KRAS mutations and immune checkpoint inhibitors will be discussed.

Source link: https://europepmc.org/article/MED/36077640


Reconstructing data-driven governing equations for cell phenotypic transitions: integration of data science and systems biology.

Cells with the same genome may exist in different phenotypes. Obtaining a sufficient amount of quantitative data for constraining model parameters is a key issue for mechanism-driven modeling studies. Advances in quantitative methods, particularly high-throughput single-cell methods, have accelerated the emergence of a new direction for reconstructing the governing dynamical equations of a cell system from quantitative single-cell results, which have surpassed previous statistical methods.

Source link: https://europepmc.org/article/MED/35998617


Lipid Raft Facilitated Receptor Organization and Signaling: A Functional Rheostat in Embryonic Development, Stem Cell Biology and Cancer.

Over the past fifty years, Molecular theories of plasma membrane organization and dynamics have been gradually evolving. Multiple signaling nexuses in eukaryotic cells are present in plasma membranes, and the kinetics of plasma membrane induces several signaling nexuses. lipid rafts are unique among other membrane subdomains in terms of usability. Specifically, how rafts dynamically harbour signaling proteins, such as GPCRs, catalytic receptors, and ionotropic receptors within it are analyzed and orchestrate multiple signaling pathways are discussed herein. The roles of plasma membrane lipid rafts in lineage specificity, early embryonic development, stem cell maintenance are all emerging. We have highlighted and discussed the roles of lipid rafts in embryonic formation, cell signaling, and gene expression during embryonic development, from pre-implantation to post-implantation, stem cell and cancer biology in view of this.

Source link: https://europepmc.org/article/MED/35997871


The Cell Biology of Charophytes: Exploring the Past and Models for the Future.

Charophytes are a complex group of extant green algae that are the sister lineage to land plants. A charophyte progenitor successfully colonized property and eventually introduced land plants, a charophyte progenitor that later gave rise to land plants. Although we are only in the beginning of elucidating charophytes' cell biology, we hope that the use of novel analytical techniques in charophyte studies, which also include a larger sample of inclusive taxa, will improve our knowledge of plant evolution and cell fate.

Source link: https://europepmc.org/article/MED/35993883


Aryl hydrocarbon receptor (AhR)-mediated signaling as a critical regulator of skeletal cell biology.

The aryl hydrocarbon receptor has been implicated in the regulation of bone progenitor cells and bone-resorbing osteoclasts, as well as bone mass and risk of skeletal fractures, as well as bone fracture prevention and bone fracture risk. The AhR also plays a vital role in the skeletal system and in the differentiation of mesenchymal stem cells into other cell lineages, including chondrocytes and adipocytes.

Source link: https://europepmc.org/article/MED/35900841


Spatial biology analysis reveals B cell follicles in secondary lymphoid structures may regulate anti-tumor responses at initial melanoma diagnosis.

In sentinel lymph nodes of melanoma patients, we wanted to investigate differences in the histological location and activation status of B cell follicles. By flow cytometry, B cell percentage in patients with tumor in LN jumped in patients with tumor in LN compared to patients with nSLN. With DSP, B cell regions from a separate cohort of patients with tumors in the vs. no tumor were compared to no tumors in the vs. no tumor study. Patients with snSLN also had significant elevated levels of several activation indicators, including Ki-67, in B cell regions of the SLN, with significant increases in B cell counts among nSLN patients. We found variation in B cell follicles that were either surrounding the tumor deposit or infiltrating the tumor in 4 patients with pSLN. Conclusion These results show that B cell follicles may play a role in coordinating effective adaptive immune responses in melanoma when low volume metastatic disease is present in tumor draining LN.

Source link: https://europepmc.org/article/MED/36052068

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions