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Abstract Celiac disease is a persistent autoimmune enteropathy that affects approximately 1% of the population. Gluten ingestion causes an immune response in genetically prone patients, resulting in intestinal and extraintestinal disease manifestations. The only approved treatment for celiac disease is a gluten-free diet with micronutrient supplementation. Primary care providers must be able to recognize screening signs, direct patients appropriately, and provide adequate patient education and follow-up.
Source link: https://europepmc.org/article/MED/35472034
Background/Objects: Objectives: Investigate the presence of seronegative celiac disease in patients with isolated refractory dyspepsia and gastroesophageal reflux disease (Gaya) in patients with isolated refractory dyspepsia and gastroesophageal reflux disease -related symptoms. Among 968 patients, 129 seronegative patients with tissue damage consistent with Marsh IIIa classification or above were included. Regardless of endoscopic appearance, biopsies were extracted from the duodenum, and patients with Marsh IIIa or above damage were encouraged to adhere to a gluten-free diet. All of the patients were healthy for the HLA-DQ2 and DQ8 haplotypes. The differences between the mean GDS scores, RSI scores, and Biagi scores before and after the gluten-free diet were statistically significant. Endoscopic appearance and histological examination findings were not significant. In this group of patients, seronegative celiac disease may be considered. Also if a patient is seronegative and has normal endoscopic findings, a duodenal biopsy should be considered.
Source link: https://europepmc.org/article/MED/35466089
The potential effect of maternal breast milk composition in children with celiac disease is unclear in children. During the first three years of life, the aim of our study was to determine the microbiota composition and the concentrations of immune markers in breast milk from mothers whose offsprings had the genetic predisposition to CD, as well as whether they did or did not have CD during follow-up. Maternal breast milk samples [CD children and healthy children] were collected three months after delivery. The Shannon 'H' diversity index and phylotype abundance were both significantly higher in breast milk samples in the CD group. In conclusion, the microbiota in breast milk from mothers of genetically predisposed offspring who appeared on CD had a greater bacterial abundance and variety, as well as a different bacterial composition, as compared to those mothers of unaffected children.
Source link: https://europepmc.org/article/MED/35459889
History In patients with juvenile idiopathic arthritis compared to the general population, a higher incidence of celiac disease has been found. Demographic, clinical, and laboratory records of all patients with JIA from January 2001 to June 2019, who underwent CD screening, were retrospectively extracted from clinical charts and analyzed. In comparison to 36. 4% of those without CD, 87. 5% patients with JIA and CD needed both a conventional Disease Modifying Anti-Rheumatic Drug and a biological DMARD over time. Conclusions In a large JIA cohort, higher CD rates were found in a large JIA cohort, supporting the need for CD screening in all JIA children, particularly those with a family history of autoimmunity, which was found to be linked to the co-occurrence of the two disorders.
Source link: https://europepmc.org/article/MED/35459143
Between 2 and 8. 8% is the incidence of celiac disease in patients with chronic autoimmune thyroiditis. A gluten-free diet in CD patients is thought to have a positive effect on CAIT. Following a GFD, thyroid stimulating hormone and thyroid-specific antibodies levels in CD patients were analyzed more closely. In total, 50 patients with both CD and CAIT as well as 45 controls were reported. Only in a portion of the research could reveal the effects of a GFD on the thyroid hormonal and immunological profile. Patients with CAIT are not yet sufficiently robust to recommend GFD to patients with CAIT.
Source link: https://europepmc.org/article/MED/35458242
To investigate possible biochemical abnormalities associated with celiac disease antibody positivity in a primary health care setting and thereby identify predictors that may potentially reduce diagnostic delay and CD underdiagnosis. CD antibody positivity was measured in the Copenhagen Primary Care Laboratory database from 2000 to 2015, and/or deamidated gliadin peptide antibody IgG 10 kU/L. We investigated differences between people with positive and negative CD antibody testing results regarding the results of biochemical experiments conducted six months before and one month after the date of the CD antibody test's date. Several biochemical abnormalities related to CD antibody positivity among individuals referred to CD antibody testing were discovered in this review.
Source link: https://europepmc.org/article/MED/35437007
Celiac disease is an autoimmune disease that is triggered by intolerance of genetically impaired individuals after ingestible grains and their products. This present review summarizes the most recent study results on the connection between CD and gluten. In addition, the formulation and function of gluten peptides related to CD, gluten testing procedures, the effects of processing on gluten and gluten-free diets are critically discussed.
Source link: https://europepmc.org/article/MED/35435771
Patients with type 1 diabetes are at a higher risk of contracting celiac disease. CD testing in the T1D group and healthy controls resulted in CD detection in 20 patients with T1D, which was troubling. The sensitivity of HLA testing from 37. 7% to 68. 9% was greatly enhanced by combining the rs3130484 with HLA-DQ2/HLA-DQ8 typing, as well as the accuracy of estimation CD determination from 57% to 78 percent, but decreased the specificity from 100% to 78. 2%. With an area under curve approaching 0. 7 percent in comparison to 0. 664 for HLA typing alone, the receiver operating characteristic curve analysis revealed the highest discrimination for the combination of both genetic tests, with an area under curve rising to 0. 6 percent. The combined MSH5 gene and HLA testing combination, which is both the test's sensitivity and predictability of the test's accuracy, as well as the first-line testing for CD in T1D patients, is not appropriate for recommending such testing.
Source link: https://europepmc.org/article/MED/35456320
Introduction In patients with chronic illnesses, sexual function is often impaired. Aim This research was conducted in both male and female celiac disease patients and sought to determine the sexual occurrence and risk factors for sexual dysfunction. The Female Sexual Function Index questionnaire assessed female sexual health. Prevalence and analysis of sexual dysfunction in celiac disease patients is the key outcome measures. Both male and female patients had elevated body mass index levels that were significantly associated with sexual dysfunction. In male celiac disease patients, the age at diagnosis was a significant predictor of sexual dysfunction. Conclusions A substantial number of celiac disease patients suffer from sexual dysfunction. Sexual dysfunction in this clinical setting is evident from the early age of diagnosis and high body mass index. In order to establish a prompt diagnosis and prompt treatment, a measure of sexual function should be included in the initial assessment of celiac disease patients.
Source link: https://europepmc.org/article/MED/35419983
Objective Evaluate the celiac disease markers within the scope of its evaluation in a pediatric population with type 1 diabetes at Hospital de Braga and determine the prevalence of CD in the study. Methods Retrospective observational study of 94 patients diagnosed with T1D at age 10 years or younger was published at the HB Outpatient Diabetology Consultation, which also included those from other hospitals. In 4 patients, we obtained a positive serological test for CD. Conclusions This report revealed that there is a higher incidence of CD in pediatric populations with TD1, when compared to the general population, and reiterated the importance of CD screening. Besides, it was found that serological testing for CD antibodies, although not the most suitable first line test, is a good screening tool and HLA typing, which can help to rule out the possibility of patients with T1D diagnosis CD.
Source link: https://europepmc.org/article/MED/35420265
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