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However, 10% to 15% of ET patients are triple-negative, indicating that patients have no apparent mutations. We present a young patient with no previous medical history who has been screened for persistent thrombocytosis. She had positive antibodies for celiac disease, and the diagnosis was confirmed by a small intestinal biopsy, which is the only diagnostic test for adult celiac disease. Before going to more costly tests, we recommend screening triple-negative ET patients for celiac disease.
Source link: https://doi.org/10.1002/ccr3.5197
Abstract The potential effects of maternal breast milk composition is uncertain in children with celiac disease. Whether or not they did or not have CD during follow-up for the first three years of life, we wanted to compare the microbiota composition and the concentrations of immune markers in breast milk from mothers whose offspring had the genetic predisposition to CD. Three months after delivery, maternal breast milk samples [CD children and healthy children] were collected [CD children and healthy children. Phylotype abundance and the Shannon'H" diversity index were both significantly elevated in breast milk samples in the CD group, with some even being significantly higher in Shannon'H" diversity index. The microbiota in breast milk from mothers of genetically impaired offspring who exhibited CD revealed a higher bacterial phylotype abundance and variety, as well as a different bacterial composition, as compared to unaffected offspring mothers.
Source link: https://doi.org/10.1038/s41598-022-10679-x
Abstract: To investigate potential biochemical abnormalities in a primary health care setting and potentially identify predictors that could help minimize diagnostic delay and CD underdiagnosis. This observational cohort study included measurements of CD antibodies in the Copenhagen Primary Care Laboratory database from 2000 to 2015; CD antibody positivity was defined as tissue transglutaminase antibody IgG or IgG 7 kU/L and/or deamidated gliadin peptide antibody IgG 10 kU/L. We investigated differences between people with positive and negative CD antibody testing results pertaining to biochemical tests that were performed six months before and one month after the date of the CD antibody test was conducted. Several biochemical abnormalities linked to CD antibody positivity among individuals referred to CD antibody testing were found in this report.
Source link: https://doi.org/10.1038/s41598-022-10492-6
Abstract Background: Compared to the general population, patients with juvenile idiopathic arthritis have a higher incidence of celiac disease. The aim of this research, by Aims, was to determine the prevalence of CD in a large Southern Italian cohort of children with JIA, their medical characteristics and disease course, and assess risk factors related to their coexistence. 87. 5% patients with JIA and CD were identified by 87. 5% of those without CD, against 48. 8% of those without CD. Compared to 36. 4% of those without CD, 87. 5% patients with JIA and CD required both a conventional Disease Modifying Anti-Rheumatic Drug and a biological DMARD over time. Conclusion In a large JIA cohort, a higher CD prevalence was found, leading to the need for CD screening in all JIA children, especially those with a family history of autoimmunity, was found to be responsible for the co-occurrence of the two diseases.
Source link: https://doi.org/10.1186/s12969-022-00689-4
Between 2 and 8. 8% incidence of celiac disease in patients with chronic autoimmune thyroiditis is estimated. CAIT has been shown to have a positive effect on patients with CD. Following a GFD, the present systematic review was carried out to find more reliable data on the increase in thyroid stimulating hormone and thyroid-specific antibodies in CD patients. In total, 50 patients with both CD and CAIT, as well as 45 controls were reported. Only in a part of the research can determine the effects of a GFD on the thyroid hormonal and immunological profile. The amount of evidence is not yet sufficient to recommend GFD to patients with CAIT.
Source link: https://doi.org/10.3390/nu14081681
Patients with type 1 diabetes are at a higher risk of developing celiac disease. The T1D group's serological CD screening as well as healthy controls allowed for CD detection in 20 patients with T1D. The receiver operating characteristic curve analysis revealed the highest discrimination for the combination of both genetic and biological studies, with an area under curve approaching 0. 7 percent in comparison to 0. 664 for HLA typing alone. HLA-DQ2/HLA-DQ8 typing for CD screening in T1D pediatric patients was shown to have poor value in CD screening. Combination of the MSH5 gene and HLA tests in combination with the rs3130484 version of the MSH5 gene and HLA tests improves both the test's sensitivity and the predictive value of the test's reliability, but, in the meantime, the resulting results are not encouraging for recommending such testing as the first-line screening for CD in T1D patients.
Source link: https://doi.org/10.3390/jcm11082223
Celiac Disease is a genetic disorder characterized by gluten exposure in genetically vulnerable individuals. Macrophages are immune cells that function as pro-inflammatory classically activated macrophages or as anti-inflammatory alternatively activated macrophages. We previously reported that the phenotype of macrophages isolated from peripheral blood of CD patients and CB2 impaired function is associated with several chronic and autoimmune disorders. M1 macrophages and a CB2 reduced expression were discovered in our new M1 macrophages and a CB2 reduced expression. In addition, we've used CD M1 macrophages in inducing CD M1 macrophage damage, which is also seen on CDs. A CB2 stimulation prompts macrophage polarization toward the anti-inflammatory M2 phenotype, reducing inflammation while also limiting epithelial dysfunction. Therefore, we propose the CB2 receptor as a potential CD therapeutic target for CD by regulating macrophage polarization and preventing mucosal barrier damage.
Source link: https://doi.org/10.3390/biomedicines10040874
These agents have quickly become an integral treatment option for tumor types since the first approval of immune checkpoint inhibitors in 2011. Here, we discuss a case of a 70-year-old male patient with widespread metastatic melanoma with rapid onset anasarca and transaminitis following the introduction of dual anti-PD-1/CTLA-4 inhibition with nivolumab and ipilimumab. The fulminant appearance of this rare irAE in patients with suspected protein-losing enteropathy on ICI is illustrated by this article, showing that clinicians must follow consistent diagnostic criteria when treating suspected irAEs.
Source link: https://doi.org/10.3389/fimmu.2022.871452
However, wheat gluten proteins cause celiac disease in 0. 5 to 1% of the general population, however, wheat gluten proteins cause celiac disease in 0. 5 to 1% of the general population. Result We found 230 distinct gliadin gene sequences from severaldiploid wheat species coding for the hexaploid bread wheat's ancestral A, B, and D genomes. T cell stimulatory epitopes in CD patients can be distinguished by sequence similarity, the average length of the polyglutamine repeats, and the presence of four peptides that have been reported as T cell stimulatory epitopes in CD patients by binding to HLA-DQ2/8. chromosome 6A, 6B, or 6D can be assigned to chromosome 6A, 6B, or 6D by sequence similarity. -gliadins from the public database of hexaploid T. aestivum can be assigned to chromosome 6A, 6B, or 6D. T. monococcum sequences, as well as those from chromosome 6A of bread wheat, have almost exclusively contained epitope glia- and glia-20, but not the intact epitopes glia- and glia-2. A number of sequences from T. speltoides, as well as a number of sequences from chromosome 6B of bread wheat, did not contain any of the four T cell epitopes tested for. T. tauschii, as well as those from chromosome 6D of bread wheat's chromosome 6D, were found to have all of these T cell epitopes in varying combinations per gene. Conclusion Our review shows that -gliadin sequences from the three genomes of bread wheat isolate into distinct groups. The four identified T cell stimulatory epitope epitopes are distributed non-randomly across the genomes, indicating that the three genomes contribute differently to epitope content.
Source link: https://doi.org/10.1186/1471-2164-7-1
Abstract The gluten analysis of foods has long had flaws, which have barred food testing authorities from issuing regulations for gluten-free foods based on final gluten content. Gluten's toxicity in celiac disease patients has yet to be tested experimentally. Gluten is a complicated mixture of proteins, and its toxicity is not fully understood.
Source link: https://doi.org/10.1186/1746-4811-4-26
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