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Methods: In Northern Sardinia, a retrospective monocentric case-control study was conducted using the medical records of 8338 outpatients scheduled for upper endoscopy between 2002 and 2021. Conclusions: Overall, G6PD deficiency was correlated with an elevated risk of CD. Logistic regression with the propensity score identified for G6PD deficiency with an OR of 1. 48 was found. Conclusions: Our results show that the enzyme defect was highly and positively linked to CD, in line with the pro-oxidant effects of the enzyme defect present in animal models and humans.
Source link: https://doi.org/10.3390/nu14091815
Contextual information on a gluten-free diet is extremely variable, and the diagnosis of celiac disease is based on serological findings, mucosal intestinal biopsy, and clinic and serologic reactions to a gluten-free diet. Objectives: To determine the interobserver histological agreement, it is necessary to compare the endoscopic and histological characteristics of adult patients with celiac disease suspicion. In 32 patients, the endoscopic results associated with the duodenal villous atrophy had been present. The endoscopic markers for celiac disease diagnosis were 60. 9%, 88. 2%, 87. 5%, and 62. 5%.
Source link: https://doi.org/10.1590/s0004-28032014000400005
Celiac disease, also known as celiac sprue, is a gluten-induced autoimmune disease of the small intestine, which is strongly related to HLA-DQ2. Despite the presence of several proline residues in the peptide that are unable to participate in amide-mediated hydrogen bonds, the gluten peptide-DQ2 complex maintains essential hydrogen bonds between the MHC and the peptide backbone, which are unlikely to participate in amide-mediated hydrogen bonds. positioning of proline residues in such a way that they do not interfere with backbone hydrogen bonding results in a decrease in the number of registers available for gluten peptides to bind to MHC class II molecules, which may have reduced the likelihood of establishing positive side-chain interactions. The HLA association in celiac disease can be explained by a superior ability of DQ2 to bind a narrow range of proline-rich gluten peptides that have survived digestive digestion and that have been deamidated by tissue transglutaminase.
Source link: https://doi.org/10.1073/pnas.0306885101
Abstract Background: In patients with juvenile idiopathic arthritis, there has been a higher incidence of celiac disease than in the general population. Resulting Demographic, scientific, and laboratory information of all patients with JIA from January 2001 to June 2019 were retrospectively extracted from clinical charts and analyzed. 87. 5% of patients with JIA and CD were reported by 87. 5% of those without CD compared to 45. 8% of those without CD. Compared to 36. 4% of those without CD, 87. 5% patients with JIA and CD required both a conventional Disease Modifying Anti-Rheumatic Drug and a biological DMARD over time. Conclusion In a large JIA cohort, a higher CD prevalence was found, proving the need for CD screening in all JIA children, particularly those with a family history of autoimmunity, was found to be related to the co-occurrence of the two diseases.
Source link: https://doi.org/10.1186/s12969-022-00689-4
Abstract The potential effect of maternal breast milk composition is uncertain in children with celiac disease. During follow-up to the first three years of life, the aim of our study was to compare the microbiota composition and the concentrations of immune markers in breast milk from mothers whose offspring had the genetic predisposition to CD, as well as whether they did or did not have CD during follow-up. Three months after delivery, Maternal breast milk samples [CD children and healthy children] were collected [CD children and healthy children]. The Shannon'H" diversity index and phylotype abundance were both significant in breast milk samples in the CD group. The microbiota in breast milk from mothers of genetically predisposed offspring who presented CD had a higher bacterial abundance and variety, as well as a different bacterial composition, as compared to the mothers of unaffected offspring.
Source link: https://doi.org/10.1038/s41598-022-10679-x
The results abound This month, we selected 31 infants from a large-scale prospective birth cohort study of infants with a first-degree cousin or CD. We then carried out rigorous multivariate association, cross-sectional, and longitudinal studies using metagenomic and metabolomic data from birth, 3 months, and six months of age to investigate the effect of genetic predisposition and environmental risk factors on gut microbiota composition, function, and metabolome before the introduction of trigger. We found that cesarean section delivery is connected to a reduced prevalence of Bacteroides vulgatus and Bacteroides dopoi, folate biosynthesis pathway, and an increased presence of hydroxyphenylacetic acid, which can be implicated in immune system dysfunction and chronic inflammation.
Source link: https://doi.org/10.1186/s40168-020-00906-w
Methods: A prospective analysis of 541 pediatric patients from January 2012 to January 2019 was conducted. The aim of this research was to determine the effectiveness of biomarkers and the relationship between TGA-IgA and EMA titers. CD diagnosis was confirmed in 113 patients, 110 of whom were IgA-TG2-positive, and 3 had IgA deficiency. Only 18 patients underwent intestinal biopsy were given intestinal biopsy. Positive results for IgA-EMA and positive results for IgA-TG2 10 ULN with IgA-EMA antibody titer 1:80 were 100% concordance between IgA-EMA and positive results for IgA-TG2 10 ULN. IgA-TG2 antibody serum levels were shown to have a positive correlation with IgA-EMA in this research.
Source link: https://doi.org/10.3390/ijerph19095020
In CD, we described the gluten proteins and both the immune response and CD. Ingestion of gluten in a CD patient is often followed by villous atrophy in the small intestine, often with other digestive signs. If a gluten-free diet isn't followed, approximately 1% of patients diagnosed with CD can experience complications, including intestinal lymphoma and hyposplenism. Given that the prevalence and incidence of CD and gluten intolerances is on the rise, the military should consider offering gluten-free Meals Ready-to-Eat to all service members. Given the DoD's rising population of fully qualified service members with essential technical expertise and eager to serve the United States, the retention of service members with CD and subsequent admission of staff with little CD that does not influence the jobs will enable the DoD access to a growing number of highly skilled service members with advanced technical skills and a desire to serve the United States. Given the retention of service members with CD will allow the DoD access to a growing population of highly trained service members with critical technical skills, who are eager to serve in the United States.
Source link: https://doi.org/10.1093/milmed/usab177
Abstract: To investigate potential biochemical differences associated with celiac disease antibody positivity in a primary health-care setting and thereby identify predictors that may help to minimize diagnostic delay and underdiagnosis of CD. CD antibody positivity was determined as tissue transglutaminase antibody IgG or IgG 7 kU/L and/or deamidated gliadin peptide antibody IgG 10 kU/L in this observational cohort study; CD antibody positivity was determined as tissue transglutaminase antibody IgA or IgG 10 kU/L. We investigated differences among people with positive and negative CD antibody tests based on biochemical tests that were conducted six months before and one month after the date of the CD antibody test was performed. Several biochemical abnormalities connected with CD antibody positivity in people referred to CD antibody testing were discovered in this report.
Source link: https://doi.org/10.1038/s41598-022-10492-6
Between 2 and 8. 8% is the incidence of celiac disease in patients with chronic autoimmune thyroiditis. CAIT can be improved if a gluten-free diet in patients with CD is reported to have a beneficial effect on CAIT. Following a GFD, a systematic review was conducted to obtain more concrete data regarding the rise in thyroid stimulating hormone and thyroid-specific antibodies in CD patients. In total, 50 patients with both CD and CAIT as well as 45 controls were recorded. Only in a portion of the studies can reveal the effects of a GFD on the thyroid hormonal and immunological profile. The level of evidence isn't yet high enough to recommend GFD to patients with CAIT.
Source link: https://doi.org/10.3390/nu14081681
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