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Celiac Disease - ClinicalTrials.gov

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Last Updated: 28 April 2022

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Improved Diagnostics of Celiac Disease in Children

Prevalence of celiac disease is on the rise in Western countries, but the majority of patients are undiagnosed due to a difficult diagnosis. Undiagnosed celiac disease contributes to increasing burden on the health care system and predisposes to serious complications. On the other hand, increasing screening in at-risk groups of celiac disease consistently finds seropositive patients with no apparent signs and/or otherwise normal small-bowel mucosal morphology. The current research's objectives are to extend the diagnostic yield and stability of the existing diagnostic techniques and identify novel non-invasive techniques and biomarkers for early detection of celiac disease. In addition, the investigators will investigate the natural history of celiac disease in screening-detected asymptomatic children and those with positive serology but not normal histology, as well as establishing a large database for future clinical and translational studies.

Source link: https://clinicaltrials.gov/ct2/show/NCT02072590


Prevention of Celiac Disease in Skåne (in Swedish - Prevention av Celiaki i Skåne)

The primary hypothesis to be tested is that a strictly gluten-free diet during the first three years of life, as well as a gradual introduction of gluten during the follow-up period, will lead to tolerance to gluten. The primary aim is to investigate the percentage of children who experience celiac disease autoimmunity and celiac disease by the age of three years.

Source link: https://clinicaltrials.gov/ct2/show/NCT03562221


Optical Enhancement Virtual Chromoendoscopy With High-definition Optical Magnification for Duodenal Mucosa Characterization in Coeliac Disease Patients.

High-definition white light endoscopy does not generally allow the observation of duodenal villous patterns, which can be difficult to determine coeliac disease. In comparison to the traditional iSCAN capabilities, the iSCAN optical enhancementTM System virtual chromoendoscopy system has been designed to enhance the blood vessels' visibility, ducts of the glands, and surface structures. Magnification endoscopy has superior diagnostic sensitivity in detecting villous atrophy in comparison to HD-WLE and can be handled by all endoscopists, according to prospective results. This study will explore how to properly distinguish duodenal mucosa in gluten-free diet nave patients with CD suspicion in an attempt to compare these findings with histology. As a second aim, we want to compare diagnostic accuracy between HD-WLE and HD-OM with an OE using histology as the gold standard for finding villous abnormalities in CD.

Source link: https://clinicaltrials.gov/ct2/show/NCT05103150

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions