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Salmonella multi-drug resistance in Salmonella is one of the main causes for foodborne outbreaks around the world. The emergence of antibiotic resistance in Salmonella has been blamed in part to reduced outer membrane proteins permeability and increased efflux pump transport. In S, the present research sought to determine the presence of OMPs in sub-lethal doses of ceftriaxone. At three separate time intervals, Typho strains were exposed to sub-MIC and half of the ceftriaxone's sub-MIC levels and investigated for differing expression of OMPs. Using real-time PCR, we discovered that the expression of OMP encode genes in reaction to ceftriaxone was also investigated. The research provides further insight into the possible involvement of OMPs in S's drug resistance. Typhi is a peptide that may help develop a therapeutic approach to combat MDR isolates of S.
Source link: https://doi.org/10.1007/s11274-022-03383-5
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