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Ceftriaxone - Europe PMC

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Last Updated: 10 September 2022

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Dissemination and genome analysis of high-level ceftriaxone-resistant penA 60.001 Neisseria gonorrhoeae strains from the Guangdong Gonococcal antibiotics susceptibility Programme (GD-GASP), 2016-2019.

Background: After Neisseria gonorrhoet FC428 was first discovered in Japan, ceftriaxone-resistant strains were disseminated globally, and the gonococcal resistance rate increased sharply, seening is. Objectives: To clarify the AMR trend from 2016-2019 and identify the molecular characteristics and evolution of ceftriaxone-resistant penA 60. 001 isolates. Methods: The minimum inhibitory concentrations against 4113 isolates were found by the agar dilution technique. To identify sequence types, N. gonorrhoeae multiantigen sequence typing, multilocus sequence typing, and N. gonorrhoe sequence typing for antimicrobial resistance were used. PenA 60. 001-resistant penicillin, tetracycline, ciprofloxacin, and cefixime were present in Guangdong Province, but were not resistant to ceftriaxone, penicillin, tetracycline, ciprofloxacin, and cefixime, but not susceptible to azithromycin and spectinomycin. The major reason for the absence of NG-MAST species was single-nucleotide polymorphisms in the porB gene. Half of penA 60. 001 strains were completely mixed with global FC428 strains.

Source link: https://europepmc.org/article/MED/34994305


Effect of sub-minimum inhibitory concentration of ceftriaxone on the expression of outer membrane proteins in Salmonella enterica serovar Typhi

Salmonella multi-drug resistance in Salmonella is one of the primary causes of foodborne outbreaks around the world. Salmonella Typhi's demise in sensitivity to first-line medications such as ceftriaxone, ciprofloxacin, and azithromycin has sparked skepticism. The emergence of antibiotic resistance in Salmonella is thought to be two main reasons. In S. Typhi, the current research sought to determine the presence of OMPs in OMPs in sub-lethal concentrations of ceftriaxone. At three separate time intervals, the S. Typhi strains were exposed to sub-MIC and half of ceftriaxone's sub-MIC levels and analyzed for different expression of OMPs. Using real-time PCR, the expression of OMP encoding genes in reaction to ceftriaxone was investigated further. The report includes information about OMPs' potential involvement in drug resistance in S. Typhi, which may help develop a therapeutic strategy to combat MDR isolates of S. Typhi.

Source link: https://europepmc.org/article/MED/IND607891889


Machine learning to predict ceftriaxone resistance using single nucleotide polymorphisms within a global database of Neisseria gonorrhoeae genomes

Neisseria gonorrhoeae is a critical global health problem 1. In this research, N. gonorrhoes genomes from the PathogenWatch database were downloaded and used to develop and test different machine learning algorithms to predict ceftriaxone susceptibility/decreased susceptibility. We tested seven different ML algorithms with 97 SNPs that are known to be associated with ceftriaxone resistance. The impact score of individual SNPs was calculated after determining the ML algorithm with the highest success metrics. The ML techniques described here may have applications for predicting AMR in other pathogens.

Source link: https://europepmc.org/article/PPR/PPR539466


Azithromycin and Ceftriaxone Differentially Activate NLRP3 in LPS Primed Cancer Cells.

Method Lung cancer and prostate cancer cell lines were primed with lipopolysaccharide to stimulate NLRP3 transcription. Cell growth and viability were determined by real-time cell analysis and Annexin V expression. Results In PC3 cells, LPS-Az enabled transcription of NLRP3, Pro-CASP-1, and Pro-IL-1u03b2 as well as Pro-IL-1u03b2, which is also missing to regulate NLRP3 and Pro-IL-1u03b2 by a cell. When it stimulated the pro-inflammatory cytokines secretion in A549 and PC3 cells, LPS-Az reduced the apparent cytokines secretion while inducing the pro-angiogenic factors. In A549 and PC3 cells, LPS-Cf suppressed the expression of NLRP3-associated genes, NLRP3 protein expression, and the inflammatory cytokine secretion. Discussion Our results indicate that Cf might have suppressed LPS-induced NLRP3, which should be considered when selecting antibiotics for cancer treatment. In contrast, Az's effect on LPS primed NLRP3 and the inflammatory cytokines production seems to vary depending on the cancer cell source.

Source link: https://europepmc.org/article/MED/36012769


Prevention of congenital syphilis using ceftriaxone in a woman with Stevens-Johnson syndrome reaction to penicillin: A case report.

Introduction The aim of this paper is to raise the baron of ceftriaxone as an alternative therapy for congenital syphilis in the event of congenital syphilis, especially if desensitization to penicillin is ineffective or ineffective. With Stevens-Johnson syndrome, a 37-year-old pregnant woman with Stevens-Johnson syndrome responded to penicillin, resulting in rapid plasma reagin was 1:64 at the infectious disease clinic. With two courses of ceftriaxone, ten days 1 g IV daily at week 12 and ten days of 250 mg IM daily, demonstrating cure, CS was prevented from a fourfold drop in RPR titer to 1:16, indicating cure. Conclusion This paper aims to raise the possibility of updating AAP guidelines accordingly, as well as raising the possibility of updating AAP guidelines accordingly. The aim of this study is to raise the possibility of adjusting AAP guidelines accordingly.

Source link: https://europepmc.org/article/MED/36072694


Prevention of congenital syphilis using ceftriaxone in a woman with Stevens–Johnson syndrome reaction to penicillin: A case report

Introduction The purpose of this paper is to raise the possibility of ceftriaxone as an alternative therapy for congenital syphilis in women who are allergic to penicillin, particularly when desensitization to penicillin is ineffective or ineffective. a case Study A 37-year-old pregnant woman with Stevens' syndrome responded to penicillin with Stevens' syndrome and Stevens'u2013Johnson syndrome; her rapid plasma reagin was 1:64 at presentation to the infectious disease clinic. paraphrasedoutput:U2022 Summary of the CDC or AAP's findings u2022 Not all pregnant women with a penicillin allergy can be desensitized in the intensive-care setting. u2022 Not all pregnant women with a penicillin allergy can be sensitized in the neonate, and ceftriaxone use in the infant can be desensitized. u2022 No such studies have been published to ensure optimal dosing and timing of ceftriae.

Source link: https://europepmc.org/article/MED/PMC9441298


Antimicrobial Activity of Ceftaroline and Comparator Agents Against Ceftriaxone-Nonsusceptible Streptococcus pneumoniae from the United States (2008-2020).

We investigated the effectiveness of ceftaroline against ceftriaxone-nonsusceptible Streptococcus pneumoniae from medical centers in the United States. In 2008-2020, Streptococcus pneumoniae isolates were serially collected from 201 medical centers and tested for susceptibility by broth microdilution techniques. Ceftriaxone-nonsusceptible, MDR, and XDR isolates were among a large group of S. pneumoniae from U. S. medical centers, including ceftriaxone-nonsusceptible, MDR, and XDR isolates.

Source link: https://europepmc.org/article/MED/35976086


The identification of phage vB_1086 of multidrug-resistant Klebsiella pneumoniae and its synergistic effects with ceftriaxone.

Background The continuing rise of Klebsiella pneumoniae resistance to antibiotics is contributing to a medical crisis. Bacteriophages have been praised as one potential therapeutic option to improve antibiotic elixibility. This paper discusses the genetic characterization and biological properties of a new bacteriophage vB_1086 and its potential for phage therapy against Klebsiella pneumoniae. Methods In our research, the double-layer agar plate technique isolated a lytic bacteriophage named vB_1086. Besides, the combination of bacteriophage and antimicrobials can effectively eliminate bacterial growth and reduce the amount of antimicrobials. These results, to a degree, reveal that phage vB_1086 can be used with antibiotics to reduce the dose of antimicrobials and aid in the elimination of bacterial resistance.

Source link: https://europepmc.org/article/MED/35985450


Effect of sub-minimum inhibitory concentration of ceftriaxone on the expression of outer membrane proteins in Salmonella enterica serovar Typhi.

Salmonella multi-drug resistance is one of the leading causes of foodborne outbreaks around the world. The emergence of antibiotic resistance in Salmonella is believed to have two factors: reduced outer membrane proteins permeability and increased efflux pump transportation. In S. Typhi, the present research sought to investigate OMPs in symbiotic or sub-lethal doses of ceftriaxone. At three separate time intervals, S. Typhi strains were exposed to sub-MIC and half of the sub-MIC levels of ceftriaxone and half of the sub-MIC concentrations were determined for different expression of OMPs. Using real-time PCR, we found that the expression of OMP encoding genes in response to ceftriaxone was investigated. The investigation uncovers information about OMPs' possible involvement in S. Typhi's drug resistance, which may help to develop a therapeutic strategy to combat MDR isolates of S. Typhi.

Source link: https://europepmc.org/article/MED/35972699


Effects of Ceftriaxone on Oxidative Stress and Inflammation in a Rat Model of Chronic Cerebral Hypoperfusion.

In a cerebral hypoperfusion rats, we investigated the underlying mechanisms and effects of CTX early post-treatment on behavior. Without any motor impairment, the 2VO rats demonstrated learning and memory deficits as well as working memory impairments. The treatment with CTX has been shown to reduce white matter formation, MDA manufacturing, and interleukin 1 beta and tumor necrosis factor alpha production, mainly in the hippocampal zone. In addition, CTX therapy may raise the expression of glia and the glial glutamate transporters, as well as the neuronal glutamate transporter.

Source link: https://europepmc.org/article/MED/36004858

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions