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Ceftriaxone - Crossref

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Last Updated: 10 September 2022

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Ceftriaxone Induced fixed drug eruption in patient with common variable immunodeficiency

With ceftriaxone, the patient had an adverse drug reaction that was unrelated by a controlled drug allergy that has posed a risk to the critical antibiotic therapy. We did phased drug allergy testing: patch tests and a dose provocative examination, wich is considered a gold standard for this type of diagnostics in the diagnostic process. The diagnosis of fixed drug eruption to ceftriaxone was confirmed by the test findings, as well as the absence of cross-reactivity with other cephalosporins in this patient.

Source link: https://doi.org/10.36691/rja1563


Ceftriaxone Treatment Preserves Cortical Inhibitory Interneuron Function via Transient Salvage of GLT-1 in a Rat Traumatic Brain Injury Model

Abstract The major mechanism for glutamate removal from synapses is a traumatic brain injury. This leads to an increase in extracellular glutamate in conjunction with a rise in glutamate release from dead and dying neurons. We tested whether ceftriaxone treatment preserved intracortical inhibition and cortical parvalbumin-positive inhibitory interneuron function in rats' motor cortex after TBI in rat motor cortex using a rat fluid percussion injury TBI model. We find that neocortical GLT-1 gene and protein expression have been significantly reduced 1 week after TBI, and ceftriaxone has reduced this transient loss. Importantly, although intracortical inhibition declines after TBI, 1 week of post-TBI ceftriaxone therapy attenuates inhibition relative to saline-treated controls, the loss of inhibition remains modestly after TBI. In ceftriaxone-treated injured rats, this finding is accompanied by a significant rise in parvalbumin gene and protein expression.

Source link: https://doi.org/10.1093/cercor/bhy328


Machine learning to predict ceftriaxone resistance using single nucleotide polymorphisms within a global database of Neisseria gonorrhoeae genomes

Abstract Neisseria gonorrhoeae is a critical global health problem. In this research, N. gonorrhoeae genomes from the PathogenWatch database were downloaded and used to train and evaluate different machine learning techniques to predict ceftriaxone susceptibility/decreased susceptibility. We tested seven different ML algorithms with 97 SNPs that are known to be associated with ceftriaxone resistance. The impact score of individual SNPs was calculated after finding the ML algorithm with the highest success metrics.

Source link: https://doi.org/10.21203/rs.3.rs-1999855/v1


Levofloxacin versus ceftriaxone and azithromycin for treating community-acquired pneumonia: a randomized clinical trial study

Background and Objectives: We compared two common antibiotic regimens for the treatment of mild to moderate CAP: levofloxacin versus a u03b2-lactam and macrolide combination, both in terms of their safety and side effects. Patients with moderate to moderate CAP were randomly divided into two groups based on their characteristics and methods. For 5-7 days, Group I received a combi-country of 1 gram ceftriaxone daily and 500 mg azithromycin per day. For five days, Group II received levofloxacin 750 mg daily. In groups I and II, there were 77 and 74 patients. On the 5th day of admission, the O saturation of group II was markedly enhanced. Group II was much better. In terms of clinical signs and hospitalization length, the group II was significantly larger. Conclusion: Hospitalized patients with moderate to moderate CAP may be able to derive more benefit from fluoroquinolone administration.

Source link: https://doi.org/10.18502/ijm.v14i4.10231


Ceftriaxone dosing based on the predicted probability of augmented renal clearance in critically ill patients with pneumonia

- Summary of the PTA with improved renal clearance in critically ill patients with community-acquired pneumonia. Patients and methods Thirty-three patients from a prospective cohort study were admitted to the ICU with low CAP and ceftriaxone 2 g administered daily. Patients had 259 total ceftriaxone concentrations, which were collected during 1 or two days. With lower serum albumin, the maximal protein-bound ceftriaxone concentration decreased. There was no predictive value in Serum albumin. When below or above the 5. 7% PARC, the d+1 cut-off, respectively, was expected to result in 81% PTA under population-based once-daily 2 g dosing, which was projected to result in 81% PTA. Conclusions Patients with a high PARC, d+1, may be able to benefit from a twice-daily 2 g ceftriaxone dosing for getting adequate exposure on the next day.

Source link: https://doi.org/10.1093/jac/dkac209


Azithromycin and Ceftriaxone Differentially Activate NLRP3 in LPS Primed Cancer Cells

Background: For infection treatment, cancer patients are given antibiotics such as macrolides and lactamides. Method: To stimulate NLRP3 transcription, we were provided with lipopolysaccharide in lung cancer and prostate cancer cell lines. Cell growth and profitability were assessed by real-time cell analysis and Annexin V expression. Results: LPS-Az initiated transcription of NLRP3, Pro-CASP-1, and Pro-IL-1b2 in A549 cells, but it failed to regulate NLRP3 and Pro-IL-1b2 in PC3 cells. Though it induced the pro-angiogenic factors in A549 and PC3 cells, LPS-Az reduced the concealment of pro-inflammatory cytokines. Cells in A549 and PC3 cells revealed that LPS-Cf suppressed the expression of NLRP3-associated genes, NLRP3 protein expression, and the inflammatory cytokine secretion. Discussion: Our results show that Cf can reduce LPS-induced NLRP3, which should be considered when selecting antibiotics for cancer therapy. In contrast, Az' effect on LPS primed NLRP3 and the inflammatory cytokines production seems to depend on the cancer cell origins.

Source link: https://doi.org/10.3390/ijms23169484


Five years of outpatient parenteral antibiotic therapy with ceftriaxone in the paediatric emergency department: what clinical features are associated with need for admission?

Background More children in Emergency Departments with acute infections are now specifically directed for outpatient parenteral antibiotic therapy, according to a study. Sparse studies also determine what clinical conditions in these children are correlated with OPAT failure. Children who were younger or exposed to systemic signs of infection, according to Wesley, children who were younger or at risk of admission were more likely to require admission. Methods We conducted a service evaluation of a single UK tertiary center paediatric ED, also known as the Royal Hospital for Sick Children Edinburgh, over a 5-year period. All children were referred to the ED for OPAT with ceftriaxone, ceftriaxone being present. Result 754 children were diagnosed with OPAT in the ED over a five-year cycle. Conclusion: Infants with acute infections to our paediatric ED who were deemed suitable by senior clinicians were not able to be handled by OPAT using ceftriaxone, younger age, and the presence of systemic characteristics were not directly related to admissions.

Source link: https://doi.org/10.1136/emermed-2021-211928


Identification of Escherichia coli and Salmonella enterica organisms with reduced susceptibility to ceftriaxone from fecal samples of cows in dairy herds

Abstract u2014 Objectives: Objective u2014Totalitiofur's contribution to the reversibility of ceftriaxone from dairy cattle feces is a report by the University of Cambridge coli and Salmonella spp recovery. No correlation was established between ceftiofur use and recovery of E coli with reduced susceptibility to ceftriaxone at the herd level. However, E coli with reduced susceptibility to ceftriaxone was more likely from cows in herds, in which Salmonella spp were also found on the day of collection than in herds in which Salmonella spp were not found. For every 454-kg increase in herd milk production, Odds of recovery of E coli with reduced susceptibility to ceftriaxone from an individual cow increased 62%. u2014No evidence was found that ceftiofur on dairy farms raised the prevalence or distribution of Salmonella spp or E coli with decreased susceptibility to ceftriaxone.

Source link: https://doi.org/10.2460/ajvr.70.3.389


Lyme Myocarditis with third-degree heart block successfully treated with an early transition from IV ceftriaxone to oral doxycycline - Case report

Background Lyme disease is a common parasitic disease that can cause a variety of and possibly severe symptoms. The recommendations for treating certain aspects of Lyme are based on poor-quality data, including for myocarditis. Ceftriaxone IV ceftriaxone is generally prescribed until the heart block is clears. Case presentation We present a case of a 31-year-old male who came to our inpatient hospital with syncope and bradycardia. His heart block increased after being started on IV ceftriaxone. Before discharging from the hospital, our patient received four doses of ceftriaxone. After discharge, he completed 2 weeks of oral doxycycline. After the patient has improved, this case supports the current IDSA recommendation of using intravenous ceftriaxone followed by oral doxycycline. More research is required into the duration and favorite agent for treating Lyme's complications.

Source link: https://doi.org/10.24911/ejmcr/173-1646534187


Determination of ceftriaxone in human plasma using liquid chromatography–tandem mass spectrometry

Cephalosporin antibiotic drug used as a first-line therapy for a variety of bacterial disorders. To minimize matrix interferences, sample preparation was carried out by protein precipitation of 100 u00b5l plasma sample in combination with phospholipid-removal techniques. Separation of chromatographic separation was achieved on an Agilent Zorbax Eclipse Plus C18 column with 2% formic acid: acetonitrile as a mobile phase at a flow rate of 0. 8 ml/min with a total run time of ten minutes. The analyte and cefotaxime were detected using the positive electrospray ionization mode and selected reaction monitoring for the precursor-product transitions m/z 55. 04. 0 (u2192324. 0) for cefotaxime. In six separate lots of sodium heparin plasma tested, Calibration response showed good linearity and matrix effects were within the u00b115% threshold.

Source link: https://doi.org/10.12688/wellcomeopenres.15141.3

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions