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Cephalosporin Cefepime is a cephalosporin and can be used in secondary peritonitis and metronidazole to treat sepsis. The aim of this research was to devise and evaluate cefepime in healthy Wistar rats' plasma and peritoneal microdialysate. Plasma extraction recovery ranged from 93. 9 to 99. 9%. For the first time, the method was developed and successfully applied in a pilot pharmacokinetic study for determining the free concentration of CEF in rats' peritoneal microdialysate.
Source link: https://onlinelibrary.wiley.com/doi/10.1002/bmc.5470
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