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Introduction Perioperative cefazolin injection for total joint arthroplasty is a first-line antibiotic approved by the American Academy of Orthopaedic Surgeons for the prevention of periprosthetic joint infections. "test dose" under anesthesia, with the intention of analyzing the clinical success of giving patients with a documented penicillin allergy a perioperative full-strength cefazolin -"test dose" under anesthesia. Only one patient with a documented PA who received cefazolin had an allergic reaction, and only one patient with a documented PA had an allergic reaction. Patients receiving cefazolin had a remarkably high PJI rate of 2. 9% compared to those receiving antibiotics other than cefazolin, which had a 5. 5% PJI rate, which was statistically significant. Conclusion This research revealed that using a complete strength test dose of cefazolin in patients with a documented PA is a safe, convenient, and cost-effective way of increasing the incidence of cefazolin administration while also decreasing the risk of PJIs.
Source link: https://europepmc.org/article/MED/36580056
Purpose (Certification): Purpose is a scientific summary of the safe use of cefazolin in patients with immunoglobulin E-mediated penicillin allergy labeling such as hives and anaphylaxis. Methods A pharmacist-led, multidisciplinary collaborative practice agreement was launched in January 2020 to help pharmacists independently tailor preoperative antibiotics to the favored cefazolin in patients with PAL if nonsevere or severe reactions had been reported. PAL patients with a severe reaction were 356 received a preoperative cephalosporin and tolerated it without a reported safety issue, including 52 patients with PAL who had previously reported anaphylaxis. Conclusion A pharmacist-led, interdisciplinary CPA in patients with PAL experience severe allergic reactions, including hives and anaphylaxis, were observed without any reported safety conditions.
Source link: https://europepmc.org/article/MED/36566496
The interaction of cefazolin with silver enhanced AgNP fluorescence intensity in AgNPs in the organic phase that leads to a micro-probe fluorimetric measurement of this antibiotic at excitation/emission wavelengths of 410/527 nm. The linear analytical range was from 0. 80 to 12. 60 ng mL -1 of cefazolin under the best operating conditions, with a detection limit of 0. 55 ng mL -1. The relative standard deviation for ten replicate measurements of 2 and 10 ng mL -1 of cefazolin was 4. 18 and 1. 8 percent, respectively.
Source link: https://europepmc.org/article/MED/36527602
Due to methicillin-susceptible Staphylococcus aureus, dosage optimized cefazolin is likely to be a safe and effective alternative to antistaphylococcal penicillins for a variety of CNS infections. To optimize PK/PD results, practitioners may consider dosing cefazolin regimens every 6 hours or a continuous infusion of 8-10 grams per day rather than 2 g IV every 8 hours, given the site of infection and high therapeutic index of cefazolin.
Source link: https://europepmc.org/article/MED/36521869
For PJI prophylaxis, we wanted to compare the efficacy of cefazolin administered within 24 and 48 hours. Methods in this retrospective review How patients were divided into two groups based on whether cefazolin was administered as a single injection of 2 g twice daily within 24 or 48 hours of surgery and the following day, respectively. In the 24- and 48-h groups, respectively, the corresponding incidence of perioperative deep PJI following primary THA was 0. 5 percent and 0. 8 percent. Conclusions Lefazolin administration within 24 h of primary THA administration may be appropriate for perioperative deep PJI.
Source link: https://europepmc.org/article/MED/PMC9721432
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