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Staphylococcus epidermis is one of the most common causes of device-associated infections due to biofilm formation. According to our findings, we investigated the impact of different subinhibitory concentrations of cloxacillin, cefazolin, clindamycin, and vancomycin on the biofilm formation of methicillin-resistant S. epidermidis. Antimicrobial susceptibility testing and minimum inhibitory/bactericidal concentrations of antimicrobial agents were determined. Moreover, Reverse-transcription quantitative real-time polymerase chain reaction revealed the presence of the biofilm-associated genes icaA and atlE. The following tables showed a high rate of resistance among MRSE strains, including 80%, 53. 3%, 33. 3 percent, 33. 3%, and 26. 6%, respectively. Besides, 73% of S. epidermidis strains were multidrug-resistant. Minimum inhibitory concentration and minimum bactericidal concentration values were found in the range of 0. 5 to 512 u03bcg/mL for cefazolin, 0. 125 to 512 u03bcg/mL for cloxacillin, 0. 125 to 512 mL for cloxacillin, 0. 125 to 64 u03bcg/mL for cloxacillin, 0. 125 to 512 u03bcg/mL for 0. 05 to 1024 u03bcg/u03bcg/mL for u03bcg/mL for u03 u03bcg/mL, mL, u03bcg/mL, bcg/mL, mL, u03bcg/mL, 4 to 1024 u03bcg/mL, 1 to 1024 e/mL and 1 to 10 In MRSE strains, subinhibitory concentrations of cloxacillin, cefazolin, and clindamycin were found to promote biofilm formation. On the other hand, in MRSE strains, exposure to subinhibitory vancomycin levels did not increase biofilm formation. These results also show that exposure to conventional antibiotics with a sub-MIC can result in biofilm induction in MRSE, thus increasing the survival and persistence of comorbid infections on several surfaces.
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