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Cefazolin - Astrophysics Data System

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Last Updated: 10 December 2021

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Population pharmacokinetic model of cefazolin in total hip arthroplasty

Cefazolin is an antibiotic suggested for infection prevention in total hip arthroplasty. The purpose of this study was to perform a population analysis of cefazolin pharmacokinetics and evaluate whether cefazolin administration must be weight adapted in THA. A population PK research study was conducted to evaluate cefazolin exposure in time compared to the restorative concentration threshold. Our PK simulations using a 2000 mg cefazolin bolus showed that cefazolin concentrations remained above the threshold throughout surgical procedure, no matter of weight or renal function.

Source link: https://ui.adsabs.harvard.edu/abs/2021NatSR..1119763L/abstract

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions