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T cell differentiation in the thymus produces CD4+ helper and cytotoxic CD8+ cells as the two key T cell lineages. CD4 + cells invariably outnumber CD8+ cells at the end of this lengthy selection process, with CD4+ cells outnumbering CD8+ cells. The skewed CD4/CD8 ratio is based on two factors: greater clone number in wild-type mice, as well as an intrinsically higher likelihood of Tcr u03b2 clonotypes for pMHCII interactions. Following the introduction of a new iNKT invariant TCR u03b1 chain, thymocyte differentiation is likely to the absence of tcr u03b2 clonotypes from the CD4 lineage-committed pre-selection program.
Source link: https://europepmc.org/article/MED/36064961
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