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Cause Of Seizure - DOAJ

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Last Updated: 02 July 2022

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Gitelman Syndrome: A Rare Cause of Seizure Disorder and a Systematic Review

One of the few inherited causes of metabolic alkalosis as a result of salt loss tubulopathy is Gitelman syndrome. It is also rarer to find normomagnesemic patients of GS with seizures as the main complication, since hypomagnesemia is considered the most common cause of abnormal seizure-related brain activity in GS patients. Interestingly, GS patients are oftentimes diagnosed during pregnancy, as the distinctive electrolyte pattern characteristic of GS is noted. GS with normal serum magnesium in a patient is the most common medical diagnosis, with seizures being the most common clinical manifestation. In GS cases, we also did a comprehensive literature review of 122 reported cases to show the prevalence of normal magnesium in GS cases, as well as an overview of clinical and biochemical variability in GS. To understand the pathophysiology of seizures in GS patients with both normal and low magnesium levels, we recommend that further research and in-depth analysis be carried out.

Source link: https://doi.org/10.1155/2019/4204907

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions