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Gitelman syndrome is one of the few inherited causes of metabolic alkalosis as a result of salt loss tubulopathy. It is even rarer to find normomagnesemic patients of GS with seizures as the key complication, since hypomagnesemia is the most common cause of abnormal foci of seizure-related brain activity in GS cases. Interestingly, patients with GS are oftentimes diagnosed during pregnancy, as the familiar electrolyte pattern similar to GS is observed. Our case involves GS with normal serum magnesium levels in a patient, with seizures being the most common medical manifestation. An summary of clinical and biochemical variability in GS showed the prevalence of normal magnesium in GS cases, as well as a comprehensive literature review of 122 reported cases to show the presence of normal magnesium in GS cases. To understand the pathophysiology of seizures in GS patients with both normal and low magnesium levels, we recommend that further research and in-depth investigation are required.
Source link: https://doi.org/10.1155/2019/4204907
About 1% of all tuberculosis cases have been identified as a meningitis, with central nervous system involvement characteristically speaking as a meningitis. We discuss the situation of a young black male who experienced with new-onset seizure. Cerebral computerized tomography from an outside hospital reportedly revealed findings concerning septic emboli. We discovered a diagnosis of CNS tuberculomas after ruling out other causes. Patients were on a course of rifampin, isoniazid, pyrazinamide, and ethambutol for two months, followed by rifampin and isoniazid to complete at least twelve months of antimicrobial therapy.
Source link: https://doi.org/10.1016/j.idcr.2019.e00599
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