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In patients with infantile esotropia, abnormal brain structural and functional characteristics were demonstrated. However, no studies have looked at the relationship between structural and functional connectivity in patients with IE. With diffusion tensor imaging and functional network construction, a structural network was established for 18 patients with IE as well as 20 age- and gender-matched healthy controls. In IE patients, the Pearson correlation between coupling measures and strabismus degree was investigated, and hierarchical regression analysis showed the same effect of age. In left caudate nucleus in IE patients, a significant reduction in SC-FC coupling score was recorded, but no brain regions had different coupling metrics for global connections or long connections, according to some brain regions. In IE patients, the age-related regulatory effect on coupling-degree correlation was distinguishing between brain regions implicated in visual processing and cognition-related brain regions.
Source link: https://europepmc.org/article/MED/36620443
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