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Caudal regression syndrome is a disorder that hinders the growth of the lower half of the body. Affected individuals may have incomplete closure of the vertebrae around the spinal cord, a fluid-filled sac on the back of the body that does or does not contain part of the spinal cord, or tufts of hair at the base of the spine. People with caudal regression syndrome may also have an abnormal side-to-side curvature of the spine. The spinal abnormalities may influence the chest's size and shape, causing breathing difficulties in some people. Individuals with caudal regression syndrome may have small hip bones with a narrow range of motion. Certain people have a dull feeling in their lower limbs. Abnormalities in the genitourinary tract of caudal regression syndrome are extremely variable. These kidney abnormalities can cause frequent urinary tract infections and progressive kidney disease. In addition, the affected individuals may have protrusion of the bladder through an opening in the abdominal wall. Symptoms of urinary function control, which is a disorder called neurogenic bladder, can cause affected individuals to have increasing difficulty in regulating urine flow. The urethra opening on the underside of the penis or unsurpassed testes can be one of the male genital anomalies. People with caudal regression syndrome may have abnormal twisting of the large intestine, an obstruction of the anal opening, soft out-pouching in the lower abdomen, or other gastrointestinal tract malformations.
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