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Cationic Liposomes - Europe PMC

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Last Updated: 02 January 2023

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Cationic biopolymer decorated Asiatic Acid and Centella asiatica extract incorporated liposomes for treating early-stage Alzheimer’s disease: An In-vitro and In-vivo investigation

Background: Asiatic acid is a naturally occurring triterpenoid derivative of Centella asiatica that has neuroprotective activity. The research sought to create an ideal oral drug delivery system to treat Alzheimer's disease and produce chitosan-embedded liposomes containing an extract from CA and compare them to the chitosan-coated liposomes of asiatic acid for oral delivery to patients in the first phases of AD. In 24 h, ex vivo permeation of CLCAE and CLAA was found to be 48. 3 percent and 85. 3 %, respectively. Conclusion: The preclinical research revealed that CLAA was found to have greater stability and an ideal oral drug delivery system for AD treatment.

Source link: https://europepmc.org/article/PPR/PPR586279


Paclitaxel-Loaded Cationic Fluid Lipid Nanodiscs and Liposomes with Brush-Conformation PEG Chains Penetrate Breast Tumors and Trigger Caspase-3 Activation.

The addition of a cone-shaped poly-lipid to PTX-loaded CLs, which consisting of a mix of PEGylated CLs PTX and PTX-containing fluid nanodiscs, according to recent research, facilitates a transition to sterically stable, higher-curvature nanoparticles consisting of a mixture of PEGylated CLs PTX and PTX-containing fluid lipid nanodiscs. At PEG coverage in the bush zone, these CLs PTX and nanodiscs PTX show significant risetake and cytotoxicity in cultured human cancer cells. We investigated the PTX loading, in vivo circulation half-life, and biodistribution of systemically administered CLs PTX and nanodiscs PTX, determining their ability to cause apoptosis in triple-negative breast-cancer-bearing immunocompetent mice.

Source link: https://europepmc.org/article/MED/36521233


Cationic Liposomes with Different Lipid Ratios: Antibacterial Activity, Antibacterial Mechanism, and Cytotoxicity Evaluations.

In several studies, cationic liposomes have been used as effective antibacterial agents due to their strong bacterial binding and bacterial toxicity. In addition, the CLs with high molar ratios of DODAC can jeopardize the bacterial wall/membrane, effectively triggering the production of reactive oxygen species. An elevated cytotoxicity level can be caused by an increasing DODAC content in CLs, as shown by the above. For example, CLs with high DODAC content may help to kill both forms of bacterial cells but not cause negligible damage to mammalian cells. We hope that a systematic review of the cytotoxicity of CLs with different DODAC contents will provide an important reference for future clinical use of cationic liposomes.

Source link: https://europepmc.org/article/MED/36559007


Cationic liposomes as promising vehicles for timolol/brimonidine combination ocular delivery in glaucoma: formulation development and in vitro/in vivo evaluation.

Glaucoma is a chronic eye disease in which the pressure inside the eye increases and leads to damage to the optic nerve, resulting in blindness. Among the glaucoma treatment drugs in glaucoma therapy, there is a specific mixture of timolol maleate and brimonidine tartrate. Liposomes are one of the most commonly used drug delivery systems to eye tissue, providing improved drug permeability and long-life in ocular tissue. It appears that the pre-selected liposomal formulation developed by thin layer hydration might be a good drug carrier to improve the efficiency of the standardized combination of timolol maleate and brimonidine tartrate, which could be used as a new drug carrier in the treatment of glaucoma.

Source link: https://europepmc.org/article/MED/36477776

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

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* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions