Cationic Complexes - Europe PMC

Combination of a cationic complexes loaded with mRNA and α-Galactose ceramide enhances antitumor immunity and affects the tumor immune microenvironment.

To improve immunotherapy's effectiveness, immunotherapy's chemotherapy could be aided by u03b1-GC-LPR's ability to promote dendritic cell maturation by significantly raising the expression of bone marrow-derived cell surface molecules and secretion of cytokines. The combination of a CDC-lPR and programmed cell death protein 1 inhibitor in vivo may have triggered natural killer cell, T cells, as well as markedly reducing immune cell migration in breast cancer patients, which has a strong antigen-specific immunity. The u03b1-GC-LPR combined with immune checkpoint inhibitors as a potential design tactic to raise the antitumor immune response, according to our report.

Source link: https://europepmc.org/article/MED/36252467

Neutral and Cationic Complexes of Silicon(IV) Halides with Phosphine Ligands.

[SiI 3 2]I]I, a yellow salt produced by SiI 4 and PMe 3 in n-hexane, which contained a trigonal bipyramidal cation with trans-phosphines. The reaction products were [SiCl 3 2 ] and [SiCl 2 ] coordinated by the triflate coordinated, with Me 3 SiX 4 2 ] and Na[BAr F] as the reaction products were five-coordinated complexes [SiCl 3 2 ] and [SiCl 3 2 ] with the triflate coordinated, although Na[SiX 4 2 ] with a coordinated three-coordinated [SiCl 3 2 coordinating] and [SiCl 3 2 coordinating]. The charge dispersion among the silicon species was also investigated by natural bond orbital analyses of the computed density functional theory wavefunctions. For the [SiX 4 2 ] and [SiX 3 2 ] complexes, the positive charge on Si decreases, and the negative charge on X declines from X = F to X = I is declining.

Source link: https://europepmc.org/article/MED/36222839

AIE-active Ir(III) complexes functionalised with a cationic Schiff base ligand: synthesis, photophysical properties and applications in photodynamic therapy.

Photodynamic therapy is a promising cancer treatment strategy. According to reports, two AIE-active Ir complexes Ir-1-N+ and Ir-2-N+ were successfully produced and delivered based on Schiff base ligands. Experimental results showed that Ir-1-N+ and Ir-2-N+ have good photophysical properties, while the corresponding nanoparticles have excellent water solubility, and 1 O 2 generation capability. Notably, Ir-2-N+ NPs can be quickly digested by mouse breast cancer cells with high biocompatibility, low dark toxicity, and excellent phototoxicity. This work demonstrates a versatile tactic for achieving effective transition metal PSs with a cationic ligand in PDT.

Source link: https://europepmc.org/article/MED/36218133

Cationic Gold(II) Complexes: Experimental and Theoretical Study.

We investigated the thermodynamics of the emergence of [Au II]+ complexes from their corresponding gold precursors and investigated their stability and spectral characteristics in the IR and visible range in the gas phase. The results reveal that the best ancillary ligands L for stabilizing gaseous [Au II]+ complexes are bidentate and tridentate ligands with nitrogen donor atoms.

Source link: https://europepmc.org/article/MED/35946558

Weak Coordinating Character of Organosulfonates in Oriented Silica Films: An Efficient Approach for Immobilizing Cationic Metal-Transition Complexes.

In a first step, thiol-based silica films were electrochemically produced on indium tin oxide substrates by co-condensation of 3-mercaptopropyltrimethoxysilane and tetraethoxysilane. In two steps: impregnation of the sulfonate functionalized silica films in an aqueous solution to iron sulfate heptahydrate; dipping of the iron-containing mesostructures in an acetonitrile solution.

Source link: https://europepmc.org/article/MED/36080210

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