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To treat pulmonary embolism, Ultrasound-facilitated catheter-directed thrombolysis is used with low-dose alteplase. According to some studies, alteplase administered between two to six hours is safe and effective, but there are no studies to back up alteplase's stability under these conditions. Alteplase was available in 500 mL, 6 mg in 150 mL, and 8 mg in 200 mL. During simulated infusion, an enzyme-linked immunosorbent assay was used to determine alteplase concentrations at time 0 and 15-minute intervals. Through 120, 240, and 360 minutes of infusion, the alteplase concentration remained within 1% of the original concentration after using RP-HPLC in the absence of ultrasound. alteplase in the presence of ultrasound gradually degraded steadily over time to 90% in 240 minutes, and 70% in 360 minutes, using RP-HPLC for measuring.
Source link: https://europepmc.org/article/MED/34507349
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