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Cataract Lens - Europe PMC

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Last Updated: 10 January 2023

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Long-term rotationalstability of AcrySof IQ Toric intraocular lens in cataract patients with myopia: a retrospective case series study

Objective: To determine the long-term rotational stability of AcrySof IQ Toric intraocular lens in cataract patients with myopia. 120 eyes of 78 cataract patients with axial length 24-mm, corneal astigmatism u2265 1. 50 D, and installation of AcrySof IQ Toric IOL guided by the Version navigation software were collected. Eye rotation less than 5'u00b0 and 10b0, rotation direction, and residual astigmatism were all measured at 24 months after operation, with best-corrected distance visual acuity, corneal astigmatism, and IOL rotation at 24u201348 months. With no statistical significance, the rotation rate of Group A was marginally higher than that of Group B. AcrySof Toric IOL can effectively treat corneal astigmatism in cataract patients with myopia and has excellent long-term rotational stability.

Source link: https://europepmc.org/article/PPR/PPR591445


CELF1 Selectively Regulates Alternative Splicing of DNA Repair Genes Associated With Cataract in Human Lens Cell Line.

We analyzed and compared AS results between human lens epithelial cells with CELF1 overexpression and control cells using transcriptome-wide methods. We finally identified 840 CELF1-regulated AS activities and discovered that CELF1-OE preferred to repress exon skiing events in SRA01/04 cells. We downloaded and reviewed a set of CELF1-RNA interactome results to explore CELF1's role in regulating AS genes. At the AS level, we discovered that 194 genes were linked and controlled by CELF1 at the AS level. By CELF1, ten genes involved in DNA repair-related pathways were also bound. CELF1-bound peaks and splicing sites of RASEs, according to Motif's report, CELF1 controls AS by binding to the AGGU[AG]AG motif in SRA01/04 cells. CELF1 could mediate AS of DNA repair-related genes by directly binding to their transcripts with distinct motif bias. CELF1's intrinsic mechanism may continue to aid in cataract formation and lens manufacture.

Source link: https://europepmc.org/article/MED/36585568


Building prediction models of clinically significant intraocular lens tilt and decentration for age-related cataract.

Objectives: To determine the risks of clinically significant intraocular lens tilt and decentration in age-related cataract patients, researchers need to investigate the risk factors and design nomogram models to determine the risks of clinically relevant intraocular lens tilt and decentration after cataract surgery. Study Objectives A total of 207 patients who underwent phacoemulsification and IOL implantation were included in the research. According to the findings of the multivariate logistic regression study, univariate and multivariate logistic regression studies were used to determine the risk factors of clinically significant IOL tilt and decentration, as well as nomogram prediction models were constructed. According to a multivariate logistic regression review, preoperative crystalline lens tilt and decentration were the risk factors for clinically significant IOL tilt and decentation. One of the routine tests before cataract surgery, particularly for toric and multifocal IOLs, should be measuring preoperative crystalline lens tilt and decentration.

Source link: https://europepmc.org/article/MED/36574752


Cataract progression following lens-sparing pars plana vitrectomy for rhegmatogenous retinal detachment.

The development of cataracts is often followed by lens-sparing pars plana vitrectomy, which is often followed by cataract formation. According to a planned sequel and then preoperatively after cataract extraction surgery was ordered, patients suffering with rhegmatogenous retinal detachment, who underwent PPV with preservation of the lens, were investigated either preoperatively and then postoperatively when cataract extraction surgery was suggested, or at the end of the study follow-up period. Since PPV, the nuclear and posterior subcapsular forms of cataract have progressed sharply, beginning at 6 months after PPV. When determining the likelihood of cataract formation after PPV, patient age and the use of silicone oil tamponade must be taken into account.

Source link: https://europepmc.org/article/MED/36543919


Mechanical protective effect of lens anterior capsule flap on corneal endothelial cells during femtosecond laser-assisted cataract surgery in a rabbit model

Purpose: During femtosecond laser-assisted cataract surgery, we wanted to investigate the effects of a novel technique using an isolated lens anterior capsule flap to shield corneal endothelial cells in rabbit eyes. Corneal endothelioscopy was performed preoperatively and postoperatively on days 3 and 7 to determine endothelial cell counts and endothelial cell loss rate. Central corneal thickness was measured before and during PODs 1, 3 and 7. respectively, 8. 8 percent and 2. 92% loss of ECC in the experimental group at POD3 and POD7, respectively, as well as 11. 3 percent and 10. 3 percent, respectively. The difference in central corneal thickness was significant between the two groups on POD 1. CCT was not significantly different between the two groups at POD 3 and POD 7. Conclusions The isolated LACF procedure greatly minimizes damage caused by ultrasonic energy and shields corneal endothelial cells during phacoemulsification.

Source link: https://europepmc.org/article/PPR/PPR587271


Roles of Toric intraocular Lens implantation on visual acuity and astigmatism in glaucomatous eyes treated with iStent and cataract surgery.

During iStent triple procedures, examining the effectiveness of toric intraocular lenses in combined cataract and minimally invasive glaucoma surgery were compared between eyes implanted with non-toric and toric IOLs. Results Preoperatively, the logarithm of the minimum angle of resolution UCVAs and refractive astigmatism were similar across the groups. The postoperative centroid magnitude and certainty eclipses of refractive astigmatism were smaller in the toric group than in the non-toric group, according to Vector estimates. Compared to 11% in the non-toric group, 78% of eyes in the toric group had 1. 0 D or less refractive astigmatism compared to 78% in the non-toric group. Conclusion When combined cataract and iStent surgery is performed in glaucomatous eyes with corneal astigmatism, using toric IOLs provides a safe alternative for improved visual results.

Source link: https://europepmc.org/article/MED/36517758

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

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* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions