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Protein phosphatase 2A, as a serine/threonine phosphatase, is essential in numerous physiological processes. We investigated the potential causes of azoospermia by focusing on meiosis initiation and spermatogenesis in C57BL/6 J mice. Ppp2ca deficiency in germ cells led to pachynema arrest, as well as significant apoptosis in germ cells and defects in programmed double-strand break repair.
Source link: https://doi.org/10.1007/s43032-022-00843-z
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