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Using isolated rat pancreatic islets, it was discovered that superoxide anions, hydrogen peroxide, and hydroxyl radicals may have been involved in the action of alloxan. Exposure of islets for 5 min to alloxan resulted in delayed glucose-stimulated insulin release. These agents' protective action was suspended due to inactivation of the enzymes or the addition of excess iron to the chelating agent prior to use with alloxan.
Source link: https://doi.org/10.2337/diab.29.3.213
Abstract Tattoo inks are made of a variety of bioactive chemicals with combined biological effects that have yet to be adequately investigated. Tattoos have been attributed to oxidative stress; however, a recent N-of-1 report found that blue tattoos may be correlated with reduced local skin oxidative stress. The present research sought to investigate the characteristics of the blue tattoo ink that may lead to its potential effects on redox homeostasis, namely the catalase and superoxide dismutase mimetic properties that have not been reported for copper phthalocyanine u2013 the key BTI component. In the experiment, Intenze-u2122 Persian blue BTI was used. In vitro, CuPC-based tattoo ink PB and both its blue and white pigment-enriched fractions demonstrate CAT and SOD-mimetic activity, with effect sizes indicating a significant dependence on the biochemical environment. BTI-based BTI can mimic antioxidant enzymes, but chemical constituents other than CuPC appear to be at least partially responsible for the BTI redox-modulating properties.
Source link: https://doi.org/10.1101/2022.01.23.477399
Several new studies have shown that Piper betle L. has a high antioxidant and inhibits enzyme activity, as well as allypyrocatechol. Objectives: The current research sought to determine the molecule of allylpyrocatecachol with SOD, CAT, GSHPx, and GSHPx to determine the lead compounds' toxicity against some antioxidant enzyme using an in silico strategy. A positive control ligand compares gallic acid as a positive control ligand, based on comparison of binding affinity, precision, and comparison of involved amino acid residues. SOD, CAT, and GHSPx receptors' binding affinity was determined by silico analysis, which was -4. 3, -6. 8, -4. 5 kcal/mol. respectively. Conclusion: Allylpyrocatechol has a promising candidate as a drug that inhibits antioxidant enzyme production, as shown by this study.
Source link: https://doi.org/10.2174/1570180820666221025120744
Results: When the experiment's findings were compared to baseline results, there was a significant decrease in the antioxidant enzyme SOD level, but not a significant decline in the Catalase level in the patients under investigation. Conclusion: The results of this current study showed that vibratory massage hammer may be an effective way to reduce oxidative stress and free radicals is not only effective in preventing and treating diseases associated with oxidation: stress, pain, injury.
Source link: https://doi.org/10.36108/jrrslasu/2202.90.0140
In diabetic diabetics with type 2 diabetic retinopathy, the present study was undertaken to see if there is any correlation between retinopathy severity and leukocyte superoxide dismutase and catalase activities and lipid peroxidation in diabetic retinopathy. MDA serums increased, while SOD and CAT operations decreased with increasing severity of diabetic retinopathy, not significantly different in compatability of the diabetes-related diseases. Our findings indicate that leukocytes in patients with type 2 diabetic retinopathy are affected by oxidative stress, which may also play a role in diabetic retinopathy pathogenesis.
Source link: https://doi.org/10.14712/18059694.2018.26
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