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Catabolic - Europe PMC

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Last Updated: 10 September 2022

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Cancer Cachexia: Signaling and Transcriptional Regulation of Muscle Catabolic Genes.

Cancer cachexia is a multifactorial disorder characterized by a substantial reduction in body mass attributed to a large decrease in body weight that is mainly caused by skeletal muscle and adipose tissue loss. For a long time, inflammatory triggers have been the primary focus when designing cytotoxics for the treatment of CC. A thorough knowledge of how deregulated signaling leads to catabolic gene expression that underlies muscle wasting. We'll also discuss the epigenetic causes involved in muscle wasting gene transcription. We conclude with reflections on the directions that may lead to new therapeutic approaches to treating CC.

Source link: https://europepmc.org/article/MED/36077789


Precise Regulation of Differential Transcriptions of Various Catabolic Genes by OdcR via a Single Nucleotide Mutation in the Promoter Ensures the Safety of Metabolic Flux.

OdcB also metabolized the highly toxic intermediate 2,6-dibromohydroquinone, which was obtained from DBHB by OdcA. In reaction to DBHB, the upregulated transcriptional level of odcB was 7- to 9fold higher than that of orf419, odcA, or odcC. DBHB was discovered to be the effector and essential for OdcR binding to all four promoters of orf419, odcB, and odcC by an electrophoretic mobility shift assay and DNase I footprinting assay, assay and odcC. A single nucleotide mutation in the promoter of odcB's regulatory binding site was discovered and demonstrated to result in the much faster transcription of odcB. DBHB's metabolic stability was ensured by tight regulation of these genes by OdcR by a single nucleotide mutation in the promoter. However, studies on how bacteria precisely regulate differential transcriptions of several catabolic genes by a joint regulator to ensure metabolic safety are lacking. In Pigmentiphaga sp, a transcriptional activator, OdcR, which greatly triggered odcB transcription for the detoxification of the flammable intermediate 2,6-dibromohydrates, and only marginally increased the transcriptions of other genes for 3,5-hydroxybenozate catabolism. This paper explores a novel and ingenious regulatory approach to guaranteeing metabolic integrity in bacteria, as well as expanding our knowledge of synergistic transcriptional control in prokaryotes.

Source link: https://europepmc.org/article/MED/36036586


Novel insights into the regulation of cellular catabolic metabolism in macrophages through nuclear receptors.

Regulating cellular catabolic metabolism in immune cells has recently emerged as a common treatment for inflammation. NRs are now regulating cellular metabolism in macrophages during inflammation steps and aid in inflammation elimination. This may have fresh ramifications for our knowledge of how NRs influence immune response responses and influence anti-inflammatory drug design.

Source link: https://europepmc.org/article/MED/35997656


Direct control of lysosomal catabolic activity by mTORC1 through regulation of V-ATPase assembly.

The amino acid sensor mechanistic target of rapamycin complex 1 is reduced by unknown mechanism in amino acid-replete environments, hampering nutritional supply of extracellular proteins. When mTORC1 is online, peripheral V-ATPase V 1 domains reside in the cytosol, where they are stabilized by their union with the chaperonin TRiC. When mTORC1 traffic decreases, V-ATPase V 1 domains in lysosomes are converted to membrane-integral V-ATPase V1 domains that can produce operational proton pumps. The resulting decrease in luminal pH leads to protease activity and protein degradation throughout the lysosomal population.

Source link: https://europepmc.org/article/MED/35977928

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions