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Abstract Background The role of the sympathetic nervous system on bone and cartilage metabolism was discussed, which expressed u03b2-adrenergic receptors. Methods of Osteritis patients were found with articulated chondrocytes and articular cartilage. With IL-1u03b2, Chondrocyte monolayer and cartilage explant culture were stimulated. The levels of u03b2 1 -, u03b2 2 -, and u03b2 3 -AR in OA cartilage and IL-1-treated chondrocytes were lower than those in normal cartilage and untreated cells, according to u03b2 2 -, u03b2 2 -, and u03b2 3 -AR. In addition, NE substantially reduced the release of glycosaminoglycan from cartilage explant culture. In addition, u03b2-AR involvement had a significant effect on IL-1-stimulated phosphorylation of JNK and ERK. These results show that the u03b2-AR signal is associated with cartilage metabolism, which is consistent with cartilage metabolism. Conclusions Our results showed that u03b2-ARs is a source of cartilage catabolism promoted by IL-1u03b2.
Source link: https://doi.org/10.1186/s12891-021-04598-7
Under IL-1u03b2 stimulation, the aim of this research was to investigate HO-1 modulation of ECM metabolism in human NP cells. HO-1 expression in IDD progression decreased dramatically during IDD progression, according to our findings. Induction of HO-1 also reversed the effects of IL-1u03b2 on the expression of the catabolic markers matrix metalloproteinases-1, 3, 9, and 13. These results show that HO-1 may play a key role in IDD, and that manipulating HO-1 expression can reduce ECM metabolism in NP, potentially giving a new therapeutic approach to the treatment of IDD.
Source link: https://doi.org/10.1038/srep21190
Abstract Aims: In individuals on maintenance haemodialysis, one of the objectives is to assess the effects of protein supplementation over nutrition education/counselling on protein intakes. Participants in the study were randomly selected and people attending those centers were invited to participate in the study. For six weeks in, the intervention group received a whey protein supplement that contained 36 grams daily. At baseline, there was no significant difference in the mean nPCR between IVG and NIVG at baseline. During protein supplementation and nutritional education/counselling 0. 17 mg/kg; P = 0. 02 phases of the study, IVG had significantly higher mean nPCR than NIVG. Among IVG, protein supplementation + u00b13. 2 mg/kg u00b1 3. 0 mg/kg, but not nutrition education/counselling resulted in a significant rise in mean nPCR compared to baseline, with no significant changes in biochemical parameters. Conclusions Among participants, the nPCR increased dramatically with protein supplementation but not nutrition education/counselling without adversely impacting biochemical variables were found.
Source link: https://doi.org/10.1093/cdn/nzz035.p12-035-19
In the final overall analysis, data from 18 studies resulting in 22 comparisons of lean mass changes were included in the final overall review. Protein intakes increased by protein intakes in lean mass relative to RDA consumption [weighted mean difference: 0. 32 kg, n = 22 comparisons]. Protein intakes were higher than RDA attenuated lean mass loss after ER [0. 36 kg, n = 14], improved lean mass after resistance training [0. 8 kg, n = 3], but did not significantly influence changes in lean mass [0. 08 kg, n = 7] under nonstressed conditions, according to the subgroup results. Adults who were clearly stressed by the anabolic stressor of RT were more likely to develop lean mass changes in lean mass, according to the RDA.
Source link: https://doi.org/10.1093/advances/nmz106
The aim of this research, therefore, is to investigate the lipid catabolic effects of sargahydroquinoic acid, one of the main bioactive chemicals of S. serratifolium by white adipocyte browning effects. Methods Isolated and Purified SHQA from S. serratifolium was used to treat 3T3-L1 preadipocytes to see the effects of lipid catabolism and white adipocyte browning. SHQA also activates not only PPARu03b3 but also PPARu03b1 and AMP-activated protein kinase u03b1, which are lipid-catabolic proteins, according to a Western Blotting and protein-ligand docking simulation. In addition, SHQA therapy markedly raised lipolysis and mitochondria in 3T3-L1 cells. Funding Sources This report was part of the initiative, which was funded by the Ministry of Oceans and Fisheries, Republic of Korea, for the manufacture of functional food products made from natural resources.
Source link: https://doi.org/10.1093/cdn/nzz031.p06-108-19
As a control group, no such meta-analysis has been published before that compares protein intakes greater than the RDA vs. the RDA. Protein intakes were higher than the RDA attenuated lean mass loss after ER [0. 41 kilogram; WMD n = 15 comparisons], but not much affected lean mass change without ER [0. 23 kg vs. n = 8], according to all comparisons] but did not have no effect on lean mass loss without ER [0. 23 kg; WMD ; RDA, n = 15 comparisons]. Protein intakes increased after RTD [0. 67 kg, n = 3], but not influence change in lean mass without RT [0. 29 kg vs. 20] n = 20]. Conclusions: Protein intakes are higher than the RDA positively influence changes in lean mass when adults are specifically stressed by the anabolic stimulator of resistance training, which is anabolic.
Source link: https://doi.org/10.1093/cdn/nzz044.p08-075-19
Muscle loss in acute infectious disease is mainly triggered by inflammation, immobilization, and hunger. Following ingestion of the dairy protein supplements u03b2-lactoglobulin, casein, and whey under controlled catabolic conditions, the aim was to compare muscle protein kinetics and metabolism. Methods We used a random crossover design to investigate 9 healthy male participants [age: 202140; BMI 20+] who were randomly assigned BLG, CAS, or WHE on three separate occasions separated by u20138 wk on three separate occasions separated by u20138 wk. To quantify muscle protein kinetics, muscle protein kinetics were determined by the forearm model and isotopic tracer techniques. According to BLG, the incremental AUC for serum insulin was 62% higher following BLG and 30% higher than WHE, as well as 25% higher in WHE relative to CAS compared to CAS. Following BLG intake, plasma levels of glucose-dependent insulinotropic peptide increased 70% compared to CAS and increased 34% compared to WHE.
Source link: https://doi.org/10.1093/jn/nxab010
We investigate in vivo functions of Rela in embryonic limbs and adult articular cartilage, and find that Rela shields chondrocytes from apoptosis by induction of anti-apoptotic genes, including Pik3r1. When homozygous knockout of Rela leads to reduced growth as a result of increased chondrocyte apoptosis, which doesn't impact growth, although heterozygous knockout of Rela does not impede growth. An articular cartilage knockout of Rela at 7 weeks leads to a dramatic rise in osteoarthritis plaque formation through increased chondrocyte apoptosis, according to a heterozygous knockout of Rela, which results in osteoarthritis formation by blockage of catabolic gene expression.
Source link: https://doi.org/10.1038/ncomms13336
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