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Caspase apoptosis cancer cells - U.S. Department of Veterans Affairs

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Last Updated: 03 November 2021

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Licochalcone A induces apoptosis in KB human oral cancer cells via a caspase-dependent FasL signaling pathway.

In the existing research study, we investigated the Lico-A-induced apoptotic results and took a look at the affiliated apoptosis path in KB human oral cancer cells. Lico-A reduced the number of practical KB oral cancer cells. KB oral cancer cells promoted with Lico-A for 24 h showed chromatin condensation by DAPI discoloration, genomic DNA fragmentation by agarose gel electrophoresis and a gradually boosted apoptotic cell population by FACS evaluation. These data recommend that Lico-A generates apoptosis in KB oral cancer cells. Additionally, Lico‑A‑induced apoptosis in KB oral cancer cells was moderated by the expression of aspect linked self-destruction ligand and triggered caspase-8 and -3 and poly polymerase. Moreover, in the KB oral cancer cells co-stimulation with a caspase prevention and Lico-A dramatically abolished the apoptotic phenomena. Our findings showed that Lico‑A-induced apoptosis in KB oral cancer cells involves the external apoptotic signaling path, which includes a caspase-dependent FasL-mediated death receptor path.

Source link: https://doi.org/10.3892/or.2013.2929

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions