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Carvedilol - Europe PMC

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Last Updated: 10 January 2023

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Validation of a quantitative multiplex LC-MS/MS assay of carvedilol, enalaprilat, and perindoprilat in dried blood spots from heart failure patients and its cross validation with a plasma assay.

Introduction Adherence to drugs is a key determinant of heart failure-related chronic illnesses. Dried blood spots are among the drug assay samples being used for drug assays due to less stringent transportation and storage requirements. Objectives: To analytically establish a LC-MS/MS scheme for simultaneous quantification of carvedilol, enalaprilat, and perindoprilat in DBS and determine the possibility of using the procedure as a determination assay as a adherence determination assay. To establish correlation and agreement between plasma and DBS samples from a pharmacokinetic pilot study, a pharmacokinetic pilot trial will help the assay further clinically by establishing correlation and agreement. For > 67 percent of samples for all analytes, the difference between the measured and estimated plasma concentrations was less than 20% of their mean. Conclusions The assay is useful as a screening device for carvedilol and perindoprilat, as well as a conformation determining assay for enalaprilat. DBS and plasma concentrations can be used interchangeably, according to Equivalence between measured and predicted plasma concentrations.

Source link: https://europepmc.org/article/MED/36568714


Validation of a quantitative multiplex LC-MS/MS assay of carvedilol, enalaprilat, and perindoprilat in dried blood spots from heart failure patients and its cross validation with a plasma assay

In DBS, carvedilol, enalapril, and perindoprilat are among the most consistent measurements of adhesion studies. u2022 Foundation for adherence studies of carvedilol, enalapril, and perindopril are shown by the DBS. u2022 Good correlation between DBS and plasma pharmacokinetic samples. Introduction Adherence to drugs is a significant determinant of heart disease-related heart failure outcomes. Dried blood samples are being used for drug assays due to less stringent transportation and storage requirements. Aims: Objectives: To quantitatively evaluate a LC-MS/MS technique for simultaneous quantification of carvedilol, enalaprilat, and perindoprilat in DBS, as well as determining the likelihood of using the technique as a adherence determination assay. For > 67 percent of samples for all analytes, the difference between the measured and estimated plasma concentrations was less than 20% of the original mean. DBS and plasma concentrations can be used interchangeably, according to Equivalence between measured and estimated plasma concentrations.

Source link: https://europepmc.org/article/MED/PMC9772843

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions