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Cartilaginous - DOAJ

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Last Updated: 10 September 2022

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The Cardiovascular and Neurotoxic Effects of the Venoms of Six Bony and Cartilaginous Fish Species

We present the cardiovascular and neurotoxic effects of the venoms from the following six fish species: Neotrygon kuhlii and Himantura toshi, as well as the Bony fish Platycephalus tricuspidata, Mugil cephalus, and Dentex tumifrons. Mean arterial pressure in the anesthetised rat was produced by all venoms except G. tricuspidata and P. fuscus. A hypotensive reaction was displayed by P. fucus venom, as well as venom from G. tricuspidata, which produced a single depressor response. The chick biventer cervicis nerve nerveu2010muscle preparation was used to investigate the in vitro neurotoxic effects of venom. In the CBCNM, tumifrons of G. tampuspidata, M. cephalus, and D. tumifrons had no effect on indirect twitches or agonist responses. In addition to collecting new data about the evolutionary relationships between venomous animals, future studies aimed at determining the molecules responsible for these effects may lead to the development of potentially new lead compounds for future pharmaceuticals.

Source link: https://doi.org/10.3390/toxins9020067


Residual hip dysplasia in children: osseous and cartilaginous acetabular angles to guide further treatment—a pilot study

Methods This review compares Hilgenreiner's bony and cartilaginous acetabular angle of 60 paediatric hips on pelvic MRI separated in two groups.

Source link: https://doi.org/10.1186/s13018-019-1441-1


Collagen from Cartilaginous Fish By-Products for a Potential Application in Bioactive Film Composite

Pepsin did not change the PSC triple helix structure, as shown by the Fourier Transform Infrared spectra report. When compared to a chitosan film, such film had lower tensile strength but increased elongation at break; and lower water solubility and lightness when compared to a collagen film. In addition, FTIR spectra analysis of film composite revealed the presence of collagen-chitosan interaction leading to a change in collagen's secondary structure. A potential UV barrier strength and antioxidant activity were shown by a Collagen-chitosan-based biofilm, which may have been used as green bioactive films to preserve nutraceutical products.

Source link: https://doi.org/10.3390/md16060211


Intra-articular injection of loaded sPL sustained-release microspheres inhibits osteoarthritis and promotes cartilaginous repairs

Using a CCK-8 cell proliferation analysis test, the effect of biological microspheres on chondrocyte proliferation was investigated. Cell morphology and cell necrosis were determined with a microscope. Biological microspheres were able to continuously release biological elements. In osteoarthritic chondrocytes, loading sPL microspheres significantly enhanced chondrocyte proliferation, reduced cell death, and elevated the expression of cartilage markers type 2 collagen, ACAN, and SOX9. As measured using Safranin-O Fast Green staining, biological microspheres also smoothen cartilage surfaces, promote proteoglycan, and type 2 collagen, as well as raising cartilage quality. Conclusions & Conclusions PLGA/chitosan/gelatin hydrogel coated with sPL is a promising tool for osteoarthritis repair that is non-invasive and non-invasive articular cartilage repair. Printed abstract Biological microspheres loaded with sPL support chondrocyte formation and upregulate chondrocyte transcription genes, resulting in an overall improved cartilaginous matrix.

Source link: https://doi.org/10.1186/s13018-021-02777-9


Bio-Ecological Features Update on Eleven Rare Cartilaginous Fish in the Central-Western Mediterranean Sea as a Contribution for Their Conservation

Cartilaginous fish are commonly recognized as a key species in marine ecosystems due to their essential ecological function as top predators. Both paper were found to be older than ten years and each had their age determinations of D. nidarosienis and L. circularis for the first time. In addition, the present research updates the numbers of first maturity of C. uyato and D. lichas in first maturity, which appeared to be reproduceing earlier than what was expected, providing more detailed information for a better understanding of these rare species populations status and, eventually, conservation.

Source link: https://doi.org/10.3390/life11090871


Propionibacterium acnes induces cartilaginous endplate degeneration by promoting MIF expression via the NF-κB pathway

However, the underlying mechanism of P. acnes-induced CEP degeneration remains unclear. In addition, we investigated the mechanism of P. acnes-induced CEP degeneration in CEP cells using western blotting and reverse transcription-quantitative polymerase chain reaction. MIF expression in the degenerated human CEP was elevated relative to that of normal human CEP, according to the authors. P. acnes induced CEP degeneration and upregulated MIF expression in a rat model, triggering CEP degeneration and elevated MIF expression. In the rat CEP cells, we determined the underlying mechanism of P. acnes-induced CEP degeneration. Moreover, P. acnes may promote MIF expression by NF-u03baB pathway rather than ERK1/2 pathway.

Source link: https://doi.org/10.1186/s13018-020-01714-6

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions