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Cartilage in Knee - Europe PMC

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Last Updated: 10 August 2022

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Defect-adaptive Stem-cell-microcarrier Construct Promotes Tissue Repair in Rabbits with Knee Cartilage Defects.

In the current research, we investigated the repair ability of stem cell microcarrier constructs in cartilage defect models. A total of 39 healthy New Zealand white rabbits were included, as well as femoral cartilage defect models, which were also established. To determine the reconstitution of cartilage defects at 12 weeks post-cartilage defect repair, a gross examination and pathological examination were done. The microcarriers could provide the defect model with high plasticity and blend well with the boundary native normal cartilage. In the microcarrier without stem cells group, the defects were filled with fibrous cartilage tissue three months after implantation. While the microcarrier loaded with BMSCs group had extensive tissue with a similar appearance of boundary cartilage, the defect was not completely smooth, the surface was not perfectly smooth. These findings point to the possibility of stem cell microcarrier construction in cartilage repair, indicating promising clinical application prospects.

Source link: https://europepmc.org/article/MED/35900693


Promising results of captopril in improving knee arthrofibrosis and cartilage status: an animal model study.

Captopril is classified as an Angiotensin-converting enzyme inhibitor, and several studies show that captopril dramatically reduced fibrosis formation in several organs, such as the liver, heart, and kidney. In an animal model, this research was conducted to determine whether captopril could be used to reduce the risk of arthrofibrosis and osteoarthritis. The control group contained 11 rabbits, and the second group contained 13 rabbits. The Osteoarthritis Research Society International scoring system evaluated Cartilage damage and osteoarthritis. Captopril significantly reduced arthrofibrosis formation based on visual scoring and the Masson trichrome staining technique, according to macroscopic and microscopic analysis. Compared to the control group, cartilage damage was reduced in the intervention group relative to the control group. Although captopril's positive preventive effect on osteoarthritis was not established scientifically, better results may be obtained if the route of administration or drug dosage is changed.

Source link: https://europepmc.org/article/MED/35900609


Melatonin Attenuates the Progression of Osteoarthritis in Rats by Inhibiting Inflammation and Related Oxidative Stress on the Surface of Knee Cartilage.

In rats, melatonin and osteoarthritis were found in a study. Forty healthy 6-month-old male SD rats were randomly divided into two groups: sham and drug intervention groups. We gave all rats an injection of papain into their knee cavity for OA modeling. In the serum of rats in each group, IL-1, IL-6, and COX-2 were found 2 weeks after the modeling was established. Also, 2 weeks after the modeling, the rats in the drug intervention group were intraperitoneally injected with melatonin antagonists intraperitoneally. The rats in the sham group were intraperitoneally injected with normal saline for two weeks. The levels of IL-1, IL-6, and COX-2 were determined in each group's serum at the second, third, and fourth weeks after the drug therapy, and the concentrations of melatonin in the serum were determined at the second week after the drug therapy. Mankin's score was determined after the rats were euthanized by cervical dislocation, and pathological sections were obtained from the knee joint to see the pathological tissue changes under microscope. Results The results of the drug experiment showed that the modelling of knee osteoarthritis in rats was successful. The Mankin scores in each period revealed statistically significant differences, according to an intergroup comparison. Conclusion Melatonin can reduce inflammation and related oxidative stress on the surface of knee cartilage. During the onset of OA in the rat knee joint, it may have been related to the repair and regeneration of articular surface cartilage.

Source link: https://europepmc.org/article/MED/35894841


Evaluation of the Efficacy of Cryopreserved Human Umbilical Cord Tissue Allograft for the Supplementation of Cartilage Defects Associated to Knee Osteoarthritis: An Observational Data Collection Study

This report is intended to publish the first efficacy results that have been obtained with the use of cryopreserved human umbilical tissue allograft for the enhancement of cartilage defects in patients with symptomatic knee osteoarthritis. 55 people were tested on a single Wharton's jelly tissue allograft application during this ongoing research. Wharton's jelly allograft suspension suspended in about 2 million L of sterile Sodium Chloride 0. 9% solution, according to the study dose. Patients with symptomatic articular cartilage defects associated with osteoarthritis of the knee joint (Wharton's jelly tissue allograft applications are safe, non-surgical, and efficacious for patients with symptomatic knee osteoarthritis.

Source link: https://europepmc.org/article/PPR/PPR523328


Treatment of knee cartilage by cultured stem cells and three dimensional scaffold: a phase I/IIa clinical trial.

The knee cartilage damage is a common condition characterized by pain and/or swelling that can greatly reduce the quality of life while also causing osteoarthritis in affected patients. Here, we sought to investigate the safety and effectiveness of cultured autologous bone marrow mesenchymal stem cells attached to the 3D Chondrotissueu00ae scaffold by autologous blood plasma coagulation in the treatment of knee cartilage defects. Methods The primary endpoint of this phase I/IIa clinical trial was to determine the effectiveness of the therapy. The secondary aim was to determine the short-to-medium medical outcomes by using standardized scoring tools such as Lysholm Knee Injury, Knee Injury, and Osteoarthritis Outcome Score, and Pain Visual Analogue Scale systems and imaging, as well as pain Visual Analogue Scale and Imaging. In all enrolled patients, the functionality of the treated knee increased within a year after surgery. EudraCT No. 12 Trial registration number and date of registration EudraCT No. 1 Trial registration number and date of registration EudraCT No.

Source link: https://europepmc.org/article/MED/35854056


Does the degree of intraoperatively identified cartilage loss affect the outcomes of primary total knee arthroplasty without patella resurfacing? A prospective comparative cohort study.

Purpose The purpose of this research was to determine if the degree of patellar cartilage loss during index surgery could influence the clinical and radiologic results of total knee arthroplasty performed without patellar resurfacing. Methods We prospectively divided 2012 patients with a minimum follow-up of 12 months into two groups according to intraoperatively graded cartilage lesions classified using the International Cartilage Repair Society's system: group 1, grades 0 to 20122 ; group 2, grades 3 to 20124. Conclusions The degree of intraoperatively identified patellar cartilage loss was not relevant to short-term outcomes after primary TKA without patellar resurfacing.

Source link: https://europepmc.org/article/MED/35851432


Comparison of the effects of autologous and allogeneic purified platelet-rich plasma on cartilage damage in a rabbit model of knee osteoarthritis.

Objective The goal of this research was to inject autologous and allogeneic P-PRP in rabbits at an early stage of KOA, and then the differences in the two P-PRPs against KOA were assessed from various perspectives, including pathological histology and immunohistochemistry. The expression of BMP-2 and Sox9 was higher in both the autologous P-PRP group and the allogeneic P-PRP group, with no difference in the expression of Sox9 in the autologous P-PRP group and the allogeneic P-PRP group compared to the model group, and the expression of BMP-2 and Sox9 was higher in both the autologous P-PRP group and the allogeneic P-PRP group in the compared to the compared to the expression in both the boosted in both the compared to the autologous P-PRP group compared to the PDP group compared to the increase in the compared to the compared to the allogenemic P-PRP group compared to the allogenemic P-PRP group compared to the allogenemic P-PRP group compared to the allogeneic P-PRP group and P-PRP group and the allogeneic P-PRP group and the allogenemic P-PRP group and the allogeneic P-PRP group BMP-2 and Sox9 were produced in chondrocytes and significantly improved KOA cartilage repair and reduced bone redundancy and joint fluid formation, as well as joint fluid formation by autologous injection, and its safety was superior to that of intra-articular injections of allogeneic P-PRP.

Source link: https://europepmc.org/article/MED/35910465

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions