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Since cartilage has a limited capacity for self-regeneration, treating cartilage degenerative disorders is a long-standing problem in orthopedic medicine. Researchers have studied cartilage tissue regeneration to compensate for cartilage tissue repair capacity deficiency. Here, we describe the construction and manufacture of the biocompatible poly acid-collagen/poly-poly-poly-poly-poly nanocomposite hydrogel with a transforming growth factor of u03b21. As an articular cartilage repair therapeutic agent, PLGA-PEG-PLGA nanoparticles were used as a delivery system embedding TGF-u203b21. Human dental pulp stem cells on PLGA-collagen/PLGA-PEG-TGF-TGF-TGF-tGF-u03b21 nanocomposite scaffolds displayed high adhesion, proliferation, and differentiation among the control groups, according to the study's findings. SEM images showed good cell adhesion and hDPSC delivery throughout the scaffolds. The expression of chondrogenic genes in hDPSCs is shown by RT-PCR assay results, which shows that TGF-2121 packed PLGA-PEG-PLGA nanoparticles puts forward chondroblast differentiation in hDPSCs. Using specific physio-chemical characteristics, a PLGA-PEG-PLGA-TGF-U3b21 nanocomposite hydrogel, according to the results, can be used as a scaffolding platform to promote hDPSCs differentiation.
Source link: https://europepmc.org/article/MED/35650332
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