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CCL formation is not limited to articular cartilage but can also be discovered in the chondro-osseous junction adjacent to the growth plate during adolescence. Cellular cartilage repair and restoration of CCL in injured cartilage can be of uleading importance due to CCL's limited self-repair capability and core role in microenvironment care. This report discusses the possibility of tissue engineering reconstruction techniques aimed at CCL for further OA treatment.
Source link: https://europepmc.org/article/MED/36131726
The aim of this research is to produce and produce a three-layered fiber/hydrogel scaffold in which each layer mimics the assembly of a critical layer of AC tissue. Three-layers of the scaffold, a fibrin-coated fibrous layer, a fibrin gel layer containing chopped fibers, and a FG embedded cylindrical aligned fibrous mat perpendicular to the articulating surface are ready, respectively serving as upper, middle, and bottom layers. According to a compressive modulus of three-layered scaffold is 13. 7 0 KPa, tensile Young's modulus of the upper layer is 152 MPa, while compressive modulus of the middle and bottom layers is 25. 3 KPa, respectively. Adding a fibrous layer to the composite scaffold layers enhances the viscoelastic behavior of FG, according to testing mechanical parameters under dynamic loading.
Source link: https://europepmc.org/article/MED/35973416
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