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The ability to: precisely specify the shape and size of scaffolds, produce intricate machinery, and minimize manufacturing wastes related to the manufacturing process are the primary benefits of additive manufacturing technologies such as three-dimensional bioprinting. However, there are already some drawbacks that must be addressed before 3D bioprinting can be used worldwide for scaffoldsu2019 production and their clinical translation. Poor availability of suitable, biocompatible, and eco-friendly biomaterials, one of them is limited by a lack of readily available, biocompatible, and eco-friendly biomaterials, which could meet a string of stringent requirements to be used and converted into a complete bioink for CTE. This paper gives an overview of 3D bioprinting for CTE in order to inform future studies into the development of more robust, customized, eco-friendly, and innovative strategies in this area of concern.
Source link: https://doi.org/10.3390/jfb13030118
The attributes of injectable hydrogels for cartilage injury include natural extracellular matrix, high biocompatibility, and good plasticity to adapt to irregular cartilage defect surfaces, among the key benefits of injectable hydrogels for cartilage injury. This paper reviews the latest academic findings on injectable hydrogels. Lastly, we review the latest advances in the latest advanced hydrogels for cartilage repair and the future challenges for injectable hydrogels.
Source link: https://doi.org/10.3389/fbioe.2022.954501
In this research, kartogenin loaded poly MPs were made by a premix membrane emulsification technique that were sonicated by ultrasound transducer. The embedded PLGA MPs could help to increase the compressive elastic modulus of soft CMC-OCS hydrogel. KGN's cumulative release KGN from MPs showed a gradual decline after ultrasound, allowing KGN to maintain a steady concentration for at least 28 days. These scaffolds did not promote rabbit bone marrow stem cell proliferation, according to LIVE/DEAD staining. Then these scaffolds were cultured with rBMMSCs for two weeks, and the immunofluorescent staining of collagen II demonstrated that CMC-OCS hydrogel embedded with MPs@KGN with ultrasound had the ability to raise the COL-2 synthesis. Overall, this injectable hydrogel with ultrasound-responsive properties is a promising device for cartilage tissue engineering, thanks to the improved mechanical property and the ability of sustained KGN production.
Source link: https://doi.org/10.3390/pharmaceutics13091487
This paper introduces the basic principles of cartilage tissue engineering and discusses recent developments in the field, with a focus on craniofacial reconstruction and facial aesthetics. Cells, scaffolds, and stimuli are among tissue engineering's basic principles. The limited implantation of chondrocytes and their ability to dedifferentiate necessitate further research into stem cell technology and chondrocyte molecular biology. To regenerate tissue efficiently, progress should be made in creating fully biocompatible scaffolds with no immune response to regenerate tissue.
Source link: https://doi.org/10.5999/aps.2020.01095
Articular cartilage damage is the most common feature of osteoarthritis and other inflammatory joint disorders. The tissue substitute must have mechanical properties that can adapt well to the joint's loading conditions in order to induce functional neocartilage formation. Polyvinyl alcohol hydrogels stand out among the slew of cartilage substitutes among the many biomaterials that can be used as cartilage substitutes, due to their high biocompatibility and tunable mechanical characteristics. This review article explores and discusses the enrichment of PVA with natural products u00b1 synthetic additives to produce cartilage substitutes with improved mechanical integrity.
Source link: https://doi.org/10.3390/pr9050730
Abstract Background Children born with a small or absent ear underwent surgical reconstruction to produce a good substitute using rib cartilage. Synthetic materials can be a helpful alternative to tackle donor site morbidity and long-term pain of harvesting rib cartilage. To improve surgical recovery's outcomes, new products for facial cartilage reconstruction are required. Polyurethanes nanocomposites scaffolds were modified with argon plasma surface modification and compared to Medpor in vitro and in vivo. Cell viability and cell growth on Ar than PU and Medpor nanocomposites scaffolds were demonstrated over 14 days increased human dermal adhesion and cell proliferation on Ar than PU and Medpor nanocomposites scaffolds. Conclusions Argon modified polyurethane nanocomposite scaffolds promote cell attachment and proliferation, tissue integration, and angiogenesis, and are a good alternative to facial cartilage replacement. Polyurethane nanocomposite scaffolds with argon surface modification are a promising biomaterial for cartilage tissue engineering applications, according to this review.
Source link: https://doi.org/10.1186/s12951-019-0477-z
Abstract Background The use of cell culture in cartilage repair options requires chondrocyte expansion for cartilage injuries. If isolation of chondrocytes and stimulation for growth and extracellular matrix synthesis can be achieved in vivo, the therapy can be carried out in a single session, and the cost can be reduced. Methods A 2. 5-cm diameter full-thickness chondral defect was discovered in five groups of sheep's knees. Some of the chondral tissues obtained from the design of the defect were diced into small pieces and inserted into the defect and covered with a collagen membrane in one group. In two sessions, Matrix-induced autologous chondrocyte implantation was administered to another group, but the last group was left untreated. After 15 weeks of follow-up, repair tissues were compared macroscopically, histomorphometrically, and biochemically for tissue samples of glycosaminoglycan and type II collagen. MACI and MIV groups demonstrated faster recovery than others, and were similar to others.
Source link: https://doi.org/10.1186/s13018-018-0823-0
Since cartilage injuries are often surgically defective, tissue-engineered scaffolds can be made to fill cartilage defects of any shape that fits snugly into the host cartilage, they are often used. GelMA/ECM-PFS has also shown that In vitro experiments showed that GelMA/ECM-PFS could slow rabbit migration. Endogenous mesenchymal stem cells from the defect site were recruited two weeks after implantation in vivo. In vivo, GelMA/ECM-PFS achieved successful hyaline cartilage repair in rabbits, while the control therapy mostly resulted in fibrous tissue repair.
Source link: https://doi.org/10.1186/s12951-021-01230-7
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