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Cartilage Tissue Engineering - Astrophysics Data System

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Last Updated: 25 September 2022

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A biomimetic three-layered fibrin gel/PLLA nanofibers composite as a potential scaffold for articular cartilage tissue engineering application

As upper, middle, and bottom layer, three-layers of the scaffold, a fibrin-coated fibrous layer, a fibrin gel layer comprising chopped fibers, and a FG embedding cylindrical aligned fibrous mat perpendicular to articulating surface were prepared. According to static mechanical analysis of the layers, tensile Young's modulus of the upper layer is 152 KPa, while compressive modulus of the middle and bottom layers is 13. 7 KPa, respectively, and compressive modulus of three-layered scaffold is 13. 7 KPa. Additionally, measuring mechanical parameters under dynamic loading reveals that adding a fibrous component to the composite scaffold layers increases the viscoelastic behavior of FG. During a seven-day cycle, insertion of 0. 2 percent chopped fibers into the fibrin matrix notably raises the equilibrium water content; however, it increases in-vitro weight loss rate from 6% to 10. 5%.

Source link: https://ui.adsabs.harvard.edu/abs/2022BioMa..17e5017R/abstract

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions