Cartilage Tissue - Springer Nature

Synovial fibroblast-miR-214-3p-derived exosomes inhibit inflammation and degeneration of cartilage tissues of osteoarthritis rats

MiRs of exosomal enclosed miRs in osteoarthritis chondrocytes and synovial fibroblasts in osteoarthritis chondrocytes and synovial fibroblasts are still poorly understood, Role of exosomal bound miRs in osteoarthritis chondrocytes and synovial fibroblasts in osteoarthritis chondrocytes and synovial fibroblasts in osteoarthritis Here, we profiled and investigated the effects of synovial fluid-derived exosomal miRs on inflammation, longevity, and chondrocyte proliferation in correlation with cartilage degeneration. The Rat model of OA was created by surgical cruciate ligament surgery and medial menisci resection. In the synovial fluid obtained from the control and OA subjects, approximately 17 miRs were found to be expressed differingly. Expression of miR-214-3p was significantly reduced in the exosome of OA subjects' synovial fluid exosome. According to a In vivo review, SFB-exosomal miR-214-3p from rats blocked osteogenesis, halted cartilage degeneration, and exerted an anti-inflammatory and anti-apoptotic effect in articular cartilage tissue. SFB-miR-214-3p exosomes, according to the study, can cause chondrocyte inflammation and cartilage tissue degeneration. The report found the therapeutic benefits of SFB-miR-214-3p exosomes in treating OA.

Source link: https://doi.org/10.1007/s11010-022-04535-9

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