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Cartilage Repair Tissue - Europe PMC

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Last Updated: 15 February 2022

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Tissue engineering and cell therapy for cartilage repair: preclinical evaluation methods.

Background and Origins: A chondral injury is a limiting disease that can influence the quality of life and be an economic burden due to immediate care's expense and poor worker productivity. If left untreated, osteoarthritis, a degenerative and debilitating joint disease characterized by pain and functional impairment, could progress to osteoarthritis, a degenerative and debilitating joint disease. In a translational and pre-clinical large animal model, this paper discusses techniques used to measure cartilage repair by tissue engineering and cell therapy methods. Experiment: A scaffold-free Tissue Engineering Construct made from dental pulp and synovial MSCs for cartilage therapy was tested in this controlled experimental study of fourteen miniature pigs. Conclusions The proposed methods were both practical and suitable to properly assess the defect filled with TEC containing stromal cells after six months of follow-up in a large animal model for articular cartilage restoration.

Source link: https://europepmc.org/article/MED/35107353


Main and Minor Types of Collagens in the Articular Cartilage: The Role of Collagens in Repair Tissue Evaluation in Chondral Defects.

Additionally, an exhaustive analysis of collagen fibrils in a recovered cartilage tissue after a chondral lesion is required to determine the consistency of the repaired tissue and whether or not this repaired tissue is considered hyaline cartilage. Consequently, this research seeks to explore all of the collagen types present in the normal articular cartilage structure, and, based on this, establish the criteria that allow one to describe a repaired cartilage tissue as a hyaline cartilage.

Source link: https://europepmc.org/article/MED/34948124


The Developing Field of Scaffold-Free Tissue Engineering for Articular Cartilage Repair.

Effective treatments for injured joint reconstruction remain a challenge, due to its poor regenerative capability, articular cartilage cannot heal on its own, and effective treatments for injured joint replacement remain a challenge. As potential therapeutic strategies to regenerate and repair damaged articular cartilage, tissue engineering has been demonstrated. Although many of these methods rely on the use of an exogenous three-dimensional scaffolds to regenerate cartilage, scaffold-free tissue engineering provides numerous advantages over scaffold-based methods.

Source link: https://europepmc.org/article/MED/34605669


Dynamic nanocomposite microgel assembly with microporosity, injectability, tissue-adhesion and sustained drug release promotes articular cartilage repair and regeneration.

Owing to a lack of blood vessels, nerves, and lymph in cartilage tissue, an articular cartilage defect is difficult to heal by self-repair. Although many cartilage tissue engineering products have been approved for clinical use, some problems such as large surgical wounds, poor adhesion to the host tissue, and a lack of autologous chondrocytes remain. The microgel assembly can prevent the cell endocytosis of nanoparticles, assures the high BMSC vivability during the basic cell culture, cryopreservation, and injection process, fostering the chondrogenic differentiation of BMSCs, according to the results, which indicate that the microgel assembly can prevent the cell death of nanoparticles, contribute to the cellular differentiation of BMSCs. In addition, the newborn cartilage samples in vivo animal testing show that the newborn cartilages have the typical characteristics of articular cartilage. This microgel assembly not only provides immediate comfort for clinical use but also provides excellent microenvironments for chondrogenesis, indicating its promising use for articular cartilage repair and regeneration.

Source link: https://europepmc.org/article/MED/34874119


Magnetic resonance observation of cartilage repair tissue (MOCART) 2.0 for the evaluation of retropatellar autologous chondrocyte transplantation and correlation to clinical outcome.

Objective Three goals were established: first, to determine whether clinical outcome correlates with particular parameters or overall results; second, to determine if clinical response correlates with specific parameters or overall findings; third, to measure those parameters for their ability to predict a clinical outcome of Delta IKDC 20 as a threshold for good clinical response at 12 months. By nonparametric Spearman's R. Those parameters with strong correlations were tested for their ability to predict a clinical outcome of Delta IKDC 20 at 12 months. Conclusion After retropatellar MACT, MOCART 2. 0 results show significant correlation with Delta IKDC scores in the postoperative course, according to a time-frame between surgery and MRI acquisition.

Source link: https://europepmc.org/article/MED/34883330

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions