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Cartilage Repair - Springer Nature

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Last Updated: 02 October 2022

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Autologous chondrocyte implantation combined with anterior cruciate ligament reconstruction: similar short-term results in comparison with isolated cartilage repair in ligament intact joints

The aim of the present study was to investigate the short-term results after autologous chondrocyte transplantation in conjunction with ACL reconstruction and to compare the results with patients with ligament intact knees. Methods The study included all patients who were registered in the German Cartilage Registry with ACI for focal cartilage defects in the knee joint in combination with ACL reconstruction, as well as a 24-month follow-up. The Knee Injury and Osteoarthritis Outcome Score and the numerical analog scale for pain were used to determine the preoperative state as well as the clinical results 12 and 24 months after surgery. Conclusion ACI at the knee joint in combination with ACL reconstruction are promising and similar to those obtained after isolated ACI in ligament intact knees.

Source link: https://doi.org/10.1007/s00167-021-06764-9


3D printing of alginate/thymoquinone/halloysite nanotube bio-scaffolds for cartilage repairs: experimental and numerical study

The printing process of bio-scaffolds is one of the recent advancements in 3D printing. Cell growth and proliferation are accelerated by 3D printing of authentic materials for cartilage repairs. According to the results, alginate and halloysite nanotube improved the printing quality and mechanical performance of biomaterials. With the 30 mg/ml of alginate, 40 mg/ml of halloysite nanotube with 5% of thymoquinone increased to 372 kPa, TMP's maximum limit, 32 kPa, Tensile strength in bio-ink climbed to 372 kPa, with 40 kPa, while compressive strain hit 894 kPa. When compared to pure alginate bioscaffolds, the biomaterial containing 30 mg/ml of alginate, 40 mg/ml of halloysite nanotube with 5% of thymoquinone showed a good mechanical and biological result. The alginic acid sodium salt/thymoquinone/halloysite nanotube mixed and 3D printed in a high-tech bioprinter, followed by mechanical and biological characteristics of printed bio-scaffolds obtained by various experimental methods, which led to a graphic abstract.

Source link: https://doi.org/10.1007/s11517-022-02654-5

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions