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Cartilage Regeneration - Wiley Online Library

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Last Updated: 02 July 2022

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Kartogenin (KGN)/synthetic melanin nanoparticles (SMNP) loaded theranostic hydrogel scaffold system for multiparametric magnetic resonance imaging guided cartilage regeneration

For theranostic purpose, we developed a novel biocompatible cellulose nanocrystal/GelMA/HAMA / Blended hydrogel scaffold system, loaded with synthetic melanin nanoparticles and a bioactive drug kartogenin. Meanwhile, continuous release of KGN may help bone-u2010derived mesenchymal stem cells proliferate and differentiate into chondrocytes, which aid cartilage regeneration in vitro and in vivo. These findings, coupled with others, established the multifunctional hydrogel as a promising tissue engineering platform for noninvasive imaging-u2010-guided precision therapy in cartilage regenerative medicine.

Source link: https://onlinelibrary.wiley.com/doi/10.1002/btm2.10364


Nanosilicateā€Reinforced Silk Fibroin Hydrogel for Endogenous Regeneration of both Cartilage and Subchondral Bone

Due to the unique biological characteristics of subchondral bone and cartilage, producing a tissue engineering scaffold that can promote dual-u2010lineage regeneration of cartilage and bone simultaneously remains a challenge. Compared to SF hydrogel, in vitro studies, SF microcomposite hydrogel had improved mechanical properties and hydrophilicity, as well as the ability to promote bone marrow stem cell differentiation with an elevated ALP activity and calcium deposition, as well as increased matrixu2010 degradation enzyme expression. Besides, it was observed that the biophysical interaction of cells and SF-u2010MMT nanocomposite hydrogel was partially mediated by clathrin-u2010mediated endocytosis and its downstream processes. In conclusion, we produced a functionalized SF-U2010MMT nanocomposite hydrogel with dual-u2010lineage bioactivity for osteochondral regeneration, showing its potential in osteochondral tissue engineering. Therefore, the SFu2010MMT nanocomposite hydrogel with dual-u2010lineage bioactivity is a promising scaffold for osteochondral tissue engineering.

Source link: https://onlinelibrary.wiley.com/doi/10.1002/adhm.202200602

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions