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Cell microencapsulation is a simple biomaterial for cell microencapsulation. Alginate hydrogel, as shown in the picture, is a popular biomaterial for cell microencapsulation. This paper seeks to determine the usability of sodium citrate buffer as a culture medium enhancer for modulating alginate microbeads' microstructure to ensure a healthy microenvironment for chondrogenic induction. Increasing the presence of SCB in the treatment medium reduced the calcium content of the microbeads and improved water absorption of the microbeads, resulting in a higher swelling ratio. In the TGF-u203b23u2010u03b23b23-u2013containing microbeads with increasing SCB levels in the treatment medium, increasing SCB expression, and corresponding extracellular matrix accumulation, glycosaminoglycans, and type II collagen were clearly visible. Our results showed that the combination of SCB treatment and TGF incorporation in the chondrocyte microbeads is a promising technique for tissue regeneration, which may lead to a versatile application in cell delivery and tissue engineering.
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