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Mesenchymal stem cells provide a promising regeneration option for degenerative cartilaginous disorders. This research was designed to compare the therapeutic effectiveness of various types of laser activated MSCs in order to encourage auricular cartilage regeneration. Group II introduced adipose-derived MSCs to one ear, Group III received bone marrow-derived MSCs, and Group IV received ear MSCs in the defected ear. A small area of immature cartilage was diagnosed with Histopathologically, ineffective areas of control positive group, ADMSCs, and EMSCs treated groups. BMMSCs had the highest chondrogenic potential compared to ADMSCs and EMSCs, and should be considered the first choice in treatment of cartilaginous degenerative disorders.
Source link: https://doi.org/10.1186/s40659-022-00408-z
Several studies have been published on the use of MSCs or EVs for tissue regeneration. We looked at the combined effects of hMSCs and EVs on cartilage regeneration by co-encapsulation in a hyaluronic-acid-based hydrogel in this research. Methods: A methacrylic-acid-based HA hydrogel was used to encapsulate hMSCs and EVs in hydrogels. Results: Co-encapsulation of hMSCs with EVs in the HA hydrogel improved the chondrogenic differentiation of hMSCs and tissue regeneration of injured cartilage tissue relative to that of the HA hydrogel loaded with hMSCs only. Conclusion: hMSCs and EVs encapsulated in a HA hydrogel efficiently improves cartilage tissue regeneration due to the combined therapeutic properties of hMSCs and EVs. This strategy, rather than cartilage tissue repair for osteoarthritis repair, may be a viable option to increase other aspects of tissue regeneration.
Source link: https://doi.org/10.1007/s13770-022-00509-6
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