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Introduction Seeding cells are the primary factors in cell-based cartilage tissue regeneration. In this study, rat costal chondrocytes and human Wharton's jelly mesenchymal stem cells were directly cocultured, as a candidate to regenerate articular cartilage. Rat CCs are directly co-cultured with hWJMSCs in a pellet model with different ratios for 21 days, according to Rat CCs. For 4, 8, 12 weeks, a 1:1 ratio co-culture pellet and monoculture controls were introduced into the osteochondral defects caused on the rats' femoral grooves by the rats' femoral grooves. Compared to the rat CCs pellet group, the 3:1 and 1:1 ratio groups demonstrated similar extracellular matrix production but with less hypertrophy aims, according to the authors. All the pellets filled the defects, according to In vitro studies, but co-culture pellets demonstrated reduced hypertrophy, improved cartilage integration, and correct subchondral bone remodeling. In vitro and vivo, co-culture of rat CCs and hWJMSCs demonstrated stable chondrogenic phenotype and reduced hypertrophic intentency.
Source link: https://doi.org/10.1186/s13287-022-03094-6
We developed a line of lignin-based nanofibers as antioxidative scaffolds for cartilage tissue engineering in this project. The PLA-lignin nanofibers protected bone marrow-derived mesenchymal stem/stromal cells from oxidative stress and promote differentiation, according to a In vitro study. In addition, the animal study found that the lignin nanofibers could aid cartilage repair and repair cartilage defects within 6 weeks after implantation. Conclusions According to our review, lignin-based nanofibers could act as an antioxidant tissue engineering scaffold and promote cartilage regeneration for OA treatment.
Source link: https://doi.org/10.1186/s12951-022-01534-2
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