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Cartilage Regeneration - Crossref

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Last Updated: 02 October 2022

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A Slotted Decellularized Osteochondral Scaffold With Layer-Specific Release of Stem Cell Differentiation Stimulators Enhances Cartilage and Bone Regeneration in Osteochondral Defects in a Rabbit Model

Purpose: Objective: To establish a tissue-engineering scaffold by tethering bone morphogenetic protein 2 and transforming growth factor beta 3 in a layer-specific way on a slotted decellularized osteochondral matrix and determining the scaffold's effectiveness for osteochondral regeneration. Methods: Bonechondral tissue from the rabbit patellofemoral groove was cut into a slot shape and decellularized for the production of a SDOM. In a rabbit model, we determined the regeneration ability of the CBD-GFs/SDOM on bone marrow mesenchymal stem cells in vitro after investigating the effects of the CBD-GFs/SDOM on the viability and layer-specific differentiation of bone marrow stem cells in vitro. A total of 72 New Zealand White rabbits with a cylindrical osteochondral defect in the patellofemoral groove were randomly assigned to three groups: defect only, defect patched with an SDOM, and defect patched with the CBD-GFs/SDOM. In vitro, the CBD-GFs/SDOM showed high biomimetics with normal osteochondral tissue, was suitable for cell adhesion and growth, and had a high rate-specific ability in inducing stem cell differentiation, as shown by layer-specificity in inducing stem cell differentiation. The CBD-GFs/SDOM group had significantly higher osteochondral regeneration than the CTL and SDOM groups, as shown by Macroscopic photographs. Compared to the defect sites in the CTL or SDOM group, no bony tissue was produced at the defect sites in the CBD-GFs/SDOM group, as opposed to the defect sites in the CTL or SDOM group. The CBD-GFs/SDOM group had a significant improvement in osteochondral recovery at 6 and 12 weeks postoperatively in comparison to the CTL or SDOM groups, according to Histological study.

Source link: https://doi.org/10.1177/03635465221114412


Review On Use Of Polymeric Hydrogel For Cartilage Regeneration.

The therapy for articular cartilage injury was a big challenge in the medical field. Hydrogel, however, played a vital role in cartilage regeneration due to its 3D cross linking capability and tissue mimicking nature. Hydrogels, on the other hand, have several specific characteristics that make them useful for a variety of biomedical applications. Further, the chemical interactions between the polymers lead to shear thinning behavior that results in stable consistency in the case of hydrogel scaffolds without the need for chemical changes. In addition, this review includes a brief summary of the key characteristics for cartilage repair applications of hydrogel scaffolds made from both natural and synthetic polymers. We investigated the multiscale characteristics of the hydrogel scaffolds, including mechanical properties and porosity. In addition, this research focuses mainly on demonstrating the characteristics of ideal polymeric hydrogels that are suitable for cartilage repair.

Source link: https://doi.org/10.22376/ijpbs/lpr.2021.11.2.p43-50


Lipid Metabolism in Cartilage Development, Degeneration, and Regeneration

Proper lipid supplementation in the diet helps maintain cartilage function, while elevated lipid buildup is detrimental to cartilage. Lipid metabolism is a complicated metabolic process that requires many regulatory entities, and different lipid metabolites have influence different characteristics of cartilage. An in-depth investigation of lipid metabolism in cartilage metabolism may help with cartilage metabolism and result in the development of new therapy techniques for metabolic cartilage damage.

Source link: https://doi.org/10.3390/nu14193984


Chondrogenic Progenitor Cells Exhibit Superiority Over Mesenchymal Stem Cells and Chondrocytes in Platelet-Rich Plasma Scaffold-Based Cartilage Regeneration

In a cartilage defect model involving mature male New Zealand White rabbits, the in vivo effects of CPCs, BMSCs, and chondrocytes on cartilage repair after PRP therapy were determined by using histopathological, biochemical, and biomechanical methods. In addition, the in vivo research found that the PRP+CPC construct gave superior histological and biomechanical results than the PRP+BMSC and PRP+chondrocyte constructs at 12 weeks after implantation. Conclusion: In PRP scaffold-based cartilage regeneration, CPCs have superiority over MSCs and chondrocytes, and PRP scaffold-based cartilage repair, and PRP+CPC therapy may be a viable option for cartilage repair, and PPC scaffold-based cartilage regeneration may be a more effective tactic for cartilage repair. Clinical Relevance: These findings support the widespread use of CPCs as a cell source in PRP-mediated cartilage regeneration and may help researchers solve the problem of unsatisfactory cell sources in cartilage engineering.

Source link: https://doi.org/10.1177/0363546519854219


Chondrogenic primed extracellular vesicles activate miR-455/SOX11/FOXO axis for cartilage regeneration and osteoarthritis treatment

The mysteriously small extracellular vesicles vesicles, according to increasing evidence, that the therapeutic benefits of BMSCs in chondrogenesis could be attributed to the uncovered small extracellular vesicles. In addition, we found that EVs derived from TGF-preconditioned BMSCs rich in miR-455 improved OA alleviation and cartilage regeneration by triggering the SOX11/FOXO signaling pathway. Our results show that in vivo, we can use biosafe engineered EVs from chondrogenic primed-BMSCs for cartilage repair and OA treatment, expanding the knowledge of chondrogenesis and OA development.

Source link: https://doi.org/10.1038/s41536-022-00250-7

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions