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Cartilage Regeneration - Astrophysics Data System

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Last Updated: 02 May 2022

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Stem cell–homing hydrogel-based miR-29b-5p delivery promotes cartilage regeneration by suppressing senescence in an osteoarthritis rat model

Here, we suggest a hydrogel-based miRNA delivery system to repair deformed cartilage by establishing a regenerative microenvironment to reduce chondrocyte senescence, which is principally responsible for cartilage loss during OA development. An injectable bioactive self-building peptide nanofiber hydrogel was used to produce agomir-29b-5p, which was functionalized by conjugating a stem cell-homing peptide SKPPGTSS for endogenous synovial stem cell proliferation simultaneously. Successful cartilage repair and chondrocyte regeneration were achieved by a sustained miR-29b-5p delivery and transplantation of synovial stem cells and their subsequent differentiation into chondrocytes. This tactic has made miRNA-based therapeutic modality a viable alternative to surgical treatment of OA patients.

Source link: https://ui.adsabs.harvard.edu/abs/2022SciA....8K..11Z/abstract


Preparation and characterization of a novel drug-loaded Bi-layer scaffold for cartilage regeneration

The photograph shows the preparation process of the cartilage scaffold, in which the hydrogel layer is loaded with aescin sodium and the fiber layer is loaded with kartogenin, as shown below. We designed and fabricated a bi-layer scaffold made from upper layer of drug-dispersed gelatin methacrylate hydrogel and a lower layer of a drug-encapsulated coaxial fiber scaffold made from silk fiber and polylactic acid in this research. Excellent drug delivery was demonstrated by the coaxial fiber structure, which allowed for drug delivery for 14 days in PBS. Cell proliferation in a bi-layer scaffold was noted in two states, notably. Cells developed on the surface of the coaxial fiber mats and became tablet-like in the coaxial fiber layer. Together, the bi-layer scaffold may play a positive role in cartilage repair, and it may be a viable therapeutic option to solve the current issues of clinical cartilage repair.

Source link: https://ui.adsabs.harvard.edu/abs/2022RSCAd..12.9524Y/abstract


Regenerative Medicine Special Feature: Supramolecular design of self-assembling nanofibers for cartilage regeneration

Bioactive biomaterials with a deterministic biomaterials' ability may have a major effect on regenerative medicine. According to review reports by growth factor binding sites, passive release of TGF-1 was slower than PA gels containing the growth factor binding sites. These materials can also help promote regeneration of articular cartilage in a rabbit model with or without the addition of an exogenous growth factor.

Source link: https://ui.adsabs.harvard.edu/abs/2010PNAS..107.3293S/abstract

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions