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Cartilage Oligomeric Matrix Protein - Springer Nature

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Last Updated: 11 January 2023

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Cartilage oligomeric matrix protein acts as a molecular biomarker in multiple cancer types

Purpose Why cartilage oligomeric matrix protein functions is to maintain the extracellular matrix's composition and stability by interacting with collagen. To investigate the correlation between COMP expression and cancer prognosis, Kaplan-u2013Meier plots were used to determine the relationship between COMP expression and prognosis of cancers. COMP was significantly overexpressed in 15 human cancers and showed no difference in 12 molecular subtypes and 16 immune subtypes. esophageal carcinoma, kidney adenocarcinoma, colon adenocarcinoma, colon adenocarcinoma, epicutaneous melanoma, prostate adenocarcinoma, renal papillary cell carcinoma, ovarian adenocarcinoma, kidney adenocarcinoma, prostate adeno carcinoma, adenocarcinoma, renal adenoma a e a a, a a, a a, a a, a a, a a, a a, a e a a, a a, a a, a COMP was a risk factor for OS, DSS, and PFI, according to previously unreported bladder urothelial carcinoma. By using J82 and T24 cells, we found that knocking down of COMP at the cell level could greatly hinder migration and invasion. COMP's findings show that it might be a promising biomarker for pan-cancer diagnosis and prognosis encompassing tumor microenvironment, disease stage, and prognosis. Conclusion This finding supports the fact that COMP is a potential biomarker for pan-cancer diagnosis and prognosis encompassing tumor microenvironment, disease stage, and prognosis.

Source link: https://doi.org/10.1007/s12094-022-02968-8

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions