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Cartilage oligomeric matrix protein, which is primarily present in cartilage, is a modulator of the extracellular matrix and is expressed primarily in cartilage. COMP expression was also recorded in breast cancer patients both in sera and tumor biopsies, and in both cases, it may have been used as a diagnostic tool. This research was designed to investigate COMP as a potential biomarker in the group of metastatic breast cancer patients. When compared to triple-negative tumors, circulating tumor cell count, and clusters, the prevalence of bone and lung metastases, correlated with elevated serum COMP in patients with ER- and HER2-positive tumors was higher in patients with ER- and HER2-positive tumors, respectively. Serum COMP results were found in patients with metastatic breast cancer, with specific forms of metastases, emphasizing that further research is required to clarify its potential as a monitoring device.
Source link: https://doi.org/10.3390/cancers13235876
According to enzyme-linked immunosorbent assay, real-time polymerase chain reaction, and immunohistochemistry, respectively, in the liver of 20 BA patients and 56 healthy controls and its mRNA and protein levels in the circulation of 96 BA patients and 56 healthy controls, as well as its mRNA and protein expressions in the liver of 20 BA patients and 5 non-BA patients and five non-BA patients and their mRNA and protein expressions in the liver of 20 BA patients and 5 output: COMP levels in ba patient blood was significantly higher than those in healthy controls, indicating significant differences in the circulation of BA patients. Raised circulating COMP scores were found to be closely related to liver fibrosis severity, according to a standardized model. Enhanced circulating COMP numbers were clearly connected with reduced survival of BA patients, according to a Survival study. Both COMP mRNA and protein expressions of BA patients with fibrosis in the liver were significantly higher than those of BA patients without fibrosis or non-BA patients.
Source link: https://doi.org/10.1038/s41598-021-95805-x
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