Advanced searches left 3/3

Cartilage Oligomeric Matrix Protein - Crossref

Summarized by Plex Scholar
Last Updated: 16 January 2022

* If you want to update the article please login/register

Cartilage oligomeric matrix protein (COMP)-induced arthritis in rats

In several rat strains, both native and denatured rat COMP resulted in severe arthritis. Disease formation seemed to be largely dependent on an immune response to autologous COMP rather than cross-reactivity to other cartilage rat collagens. The MHC's genetically modified the disease and immune response to COMP were genetically modified by the MHC; the RT1u and RT1l haplotypes were more prone than the a, c, d, f, and n haplotypes; the RT1l and RT1l haplotypes were more vulnerable than the a, c, d, f, and n haplotypes. These results show that the induction of arthritis in rats with rat COMP is a peculiar pathogenesis governed by different genes in comparison to collagen-induced arthritis or adjuvant-induced arthritis.

Source link: https://doi.org/10.1046/j.1365-2249.1998.00739.x


COMP (Cartilage Oligomeric Matrix Protein), a Novel PIEZO1 Regulator That Controls Blood Pressure

Background: Vascular endothelial cells are essential for maintaining blood pressure by secretly secretion of biologically active substances, such as nitric oxide. An electron paramagnetic resonance analysis technique was used to detect Nitric oxide. COMP / mice had elevated BP and impaired acetylcholine-mediated endothelium-dependent relaxation relative to wild-type mice with or without AngII. COMP was directly connected to Piezo1's C-terminus by its C-terminus, triggering intracellular Ca 2+ migration, Ca 2+ /calmodulin-dependent protein kinase type II, eNOS activation, and nitric oxide production. In wild-type and COMP // mice, the Piezo1 activator, Yoda1, reduced the difference in endothelium-dependent relaxation and BP. Moreover, COMP overexpression has increased eNOS activation and enhanced endothelium-dependent relaxation and BP. COMP is a novel Piezo1 regulator that helps with BP control by increasing cell Ca 2+ influx, eNOS activity, and nitric oxide production, according to our report.

Source link: https://doi.org/10.1161/hypertensionaha.121.17972


Cartilage Oligomeric Matrix Protein–Derived Peptides Secreted by Cartilage Do Not Induce Responses Commonly Observed during Osteoarthritis

Objective Objectives: To determine if three peptides derived from cartilage oligomeric matrix protein, which damaged zones of cartilage cover to synovial fluid, had biological integrity and could potentially be interested in the regulation of particular aspects of joint regeneration. The gene expression of COMP in osteochondral progenitor cells was not affected by any of the peptides. Endothelial cells' vascularization capability was not affected by the study. When peptides were introduced, there were no differences in cultured synovium explants or proinflammatory cytokines.

Source link: https://doi.org/10.1177/1947603520961170


Cartilage oligomeric matrix protein is an endogenous β-arrestin-2-selective allosteric modulator of AT1 receptor counteracting vascular injury

An extracellular matrix protein, cartilage oligomeric matrix protein, acts as an endogenous allosteric biased modulator of the AT1 receptor, and its deficiency is clinically associated with abdominal aortic aneurysm formation. Through allosteric control of AT1 intracellular conformational states, the AT1's extracellular N-terminus of the AT1 increases directly interacts with the AT1's extracellular N-terminus through its EGF domain, but not Gq or Gi signaling, but not in a specific manner.

Source link: https://doi.org/10.1038/s41422-020-00464-8


High Levels of Expression of Cartilage Oligomeric Matrix Protein in Lymph Node Metastases in Breast Cancer Are Associated with Reduced Survival

Cartilage oligomeric matrix protein, a precursor of the extracellular matrix, is primarily present in cartilage, and is predominantly present in cartilage. Complementary expression was also found in breast cancer patients both in sera and tumor biopsies, and in both cases, it could be used as an independent prognostic marker. This research was conducted in the hopes of identifying COMP as a potential biomarker in the community of metastatic breast cancer patients. In serum samples of 141 metastatic breast cancer patients, ELISA measured COMP. When compared to triple-negative tumors and correlated with bone and lung metastases, circulating tumor cell count, and clusters, the presence of serum COMP was higher in patients with ER- and HER2-positive tumors. Serum COMP results were linked to particular types of metastases in patients with metastatic breast cancer, emphasizing that further research is needed to clarify its potential as a monitoring marker.

Source link: https://doi.org/10.3390/cancers13235876

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions