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Cartilage Matrix - Wiley Online Library

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Last Updated: 02 February 2022

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An additive manufacturing‐based 3D printed poly ɛ‐caprolactone/alginate sulfate/extracellular matrix construct for nasal cartilage regeneration

Various composite scaffolds with different fabrication techniques have been used in cartilage tissue engineering. The scaffold was tested on the optimized scaffold to determine mechanical properties and chondrogenic differentiation, and the results showed that the scaffold demonstrated mechanical similarity to the native nasal cartilage tissue as well as having appropriate biochemical characteristics, making this new formulation based on PCL/dECM/Alg:Alg:Sul a promising candidate for further in-vivo studies.

Source link: https://onlinelibrary.wiley.com/doi/10.1002/jbm.a.37363


Fewer daily steps are associated with greater cartilage oligomeric matrix protein response to loading post‐ACL reconstruction

Following anterior cruciate ligament reconstruction, Aberrant joint loading contributes to posttraumatic knee osteoarthritis formation following anterior cruciate ligament reconstruction; yet little is known about the relationship between joint loading related to daily walking and cartilage health postACLR. Following a standard walking routine and daily walking in people with ACLR and uninjured controls, the aim of this research was to determine if there is a correlation between changes in serum cartilage oligomeric matrix protein, a mechanosensitive biomarker that is associated with osteoarthritis progression, and osteoarthritis progression. Following walking in people with ACLR, there were more daily steps and less minutes spent in a 100-step/min for increased %COMP; no statistically significant associations existed in controls. Individuals with ACLR who do less regular walking receive a higher % COMP, which may indicate greater cartilage loss or turnover in response to walking.

Source link: https://onlinelibrary.wiley.com/doi/10.1002/jor.25268


Modulation of the inflammatory response to decellularized collagen matrix for cartilage regeneration

Decellularized extracellular matrices are one of the most common types of tissue engineering materials due to their cell instructive properties, biodegradability, and accessibility. A natural collagen type II matrix can be a promising way to provide the necessary cues and assistance for chondrogenic stem and progenitor cells, particularly in cartilage. Our results reveal that the xenogeneic collagen matrix may provoke a mixed reaction in human macrophages, whereby inflammation response and the activation of remodeling macrophages are both present. In addition, we present the inhibitory effect of macrophage response on human CSPCs' migration capacity.

Source link: https://onlinelibrary.wiley.com/doi/10.1002/jbm.a.37349


Cadherin‐11 promotes the mechanical strength of engineered elastic cartilage by enhancing extracellular matrix synthesis and microstructure

The field of auricular cartilage tissue engineering has been prompted by limitations of recent treatments for auricular cartilage defects. In addition, the CDH11 overexpressed chondrocytes stimulated neogenesis and its biomechanical properties by raising the key transcription factor of chondrogenesis SOX9 expression and cartilage extracellular matrix production. The young's modulus and yield stress of the neo-cartilage in the CDH11 overexpression group were about 1. 7 times and 2 times higher than those in the control group, respectively. Similarly to the control group, the neo-cartilage's collagen and elastic fibers were more uniform and compact in bunches, according to the electron microscopy findings. Our results showed that CDH11 enhances the mechanical stability of tissue-engineered elastic cartilage by promoting ECM synthesis and elastic fiber assembly, which should be taken together.

Source link: https://onlinelibrary.wiley.com/doi/10.1002/term.3271

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions