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Background: Young patients with osteoarthritic knees are a difficult group because of a combination of high functional demands and no hint of joint replacement. Purpose: To evaluate the possibility of the cartilage regenerative strategy by reporting the results and failures of matrix-assisted autologous chondrocyte transplantation in a mid-term follow-up. MACT was a salvage procedure for forty-four patients with cartilage lesions in osteoarthritic knees. Patients were prospectively assessed with the help of the globally unbiased International Knee Documentation Committee, EuroQol's visual analog scale, and Tegner's preoperative results were determined at 1, 2, and 5 years; at a final assessment at a nine-year mean follow-up, with a retrospective assessment at 9 years' mean follow-up. 0. 6 at the final follow-up — the mean IKDC subjective score increased from 38. 0 15. 8 to 67. 0 18. 3 at two years, with a subsequent decrease to 57. 8 20. 6 at the final follow-up. At all follow-ups, the activity level revealed by the Tegner score increased, but not to the point of achieving the pre-injury level. The analysis of the influencing factors revealed the importance of the meniscus condition, revealing a significantly reduced result in knees with previous or combined partial meniscectomy procedures. Half of the patients thought their condition was not better than before the surgery, and 39% did not repeat the therapy considering the findings found. For this indication, Tissue-engineered cartilage implantation is questionable, but the limitations of this scaffold-based procedure must be considered if it is used as a recovery therapy for young patients with knee osteoarthritis.
Source link: https://doi.org/10.1177/0363546512463675
Background: A biomarker for cartilage degradation, serum cartilage oligomeric matrix protein, is a biomarker of cartilage degradation. It's unknown what effect intense, regular physical fitness has on athletes' sCOMP ratings and PRO values over the course of a soccer season. It's unclear what effect intense, regular physical fitness has on sCOMP levels and PRO values in athletes. Hypothesis/Purpose: The aim of this investigation was to longitudinally document sCOMP levels and to determine whether changes in PROs existed in collegiate soccer players during a season. The hypotheses, which were tested, were that sCOMP scores and PRO ratings would remain stable over the course of the spring soccer season. However, the differences in sCOMP scores did not reach the calculated minimum detectable change value, and PRO scores did not reach previously reported MDC figures, which did not reach previously estimated MDC values. Despite the fact that these results are unlikely to be scientifically relevant, this biomarker may have the ability to be used in future research studies into the effects of exercise on overall joint health in longitudinal studies.
Source link: https://doi.org/10.1177/0363546512458260
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