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Cartilage Matrix - BioProject

Summarized by Plex Scholar
Last Updated: 02 November 2021

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Single cell RNA-seq analysis links respiratory dysfunction to an extracellular matrix-specific damage response in cartilage

Here, we utilized scRNA-seq analysis to discover the value of respiration for extracellular matrix homeostasis in fully grown cartilage. Genetic inhibition of respiration in cartilage leads to the growth of a central area of 1-month-old mouse thigh head cartilage revealing topsy-turvy chondrocytes and enhanced deposition of extracellular matrix material. scRNA-seq analysis identified a cluster-specific decrease in mitochondrial DNA-encoded respiratory chain genetics and a distinct policy of extracellular matrix-related genetics in nonarticular chondrocyte collections. These changes were connected with alterations in extracellular matrix structure, a shift in the collagen/non-collagen healthy protein content and a boost of collagen crosslinking and ECM rigidity.

Source link: https://www.ncbi.nlm.nih.gov/bioproject/724687

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions