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Cartilage - Wiley Online Library

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Last Updated: 10 September 2022

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Grading cartilage damage with diffuse reflectance spectroscopy: optical markers and mechanical properties

Osteoarthritis is one of the most common joint disorders worldwide. The knee joint degeneration that occurs as a result of tissue damage can be prevented from progressing. The water content obtained by DRS strongly correlates with the cartilage thickness and viscoelastic relaxation time, according to DRS' report. The modified approach may be a valuable addition to arthroscopy, aiding in the detection of lesions at the microscopic level in the early stages of OA and supporting surgical analysis.

Source link: https://onlinelibrary.wiley.com/doi/10.1002/jbio.202200149


Recent progress of bioinspired cartilage hydrogel lubrication materials

In the field of biomedical products, the design of high-performance cartilageu2010inspired hydrogel lubrication materials has emerged as a hot topic. Subsequently, several of the novel biomimetic design techniques for producing high strength cartilage hydrogels with diverse network mesh designs are recapped in detail, and systematic evaluation of lubrication properties and mechanisms is addressed. Several bonding techniques to decorate hydrogels on surfaces of natural bone tissues or artificial joint materials are also introduced in order to demonstrate the application of cartilage hydrogels in clinical.

Source link: https://onlinelibrary.wiley.com/doi/10.1049/bsb2.12047


Thermogelling hydrogel charge and lower critical solution temperature influence cellular infiltration and tissue integration in an ex vivo cartilage explant model

In an ex vivo cartilage explant model with less than 21 days, three hydrogels based on poly and crosslinked with a peptide-u2010bearing macromer polyu2010polyu2010poly and lower critical solution temperature were manufactured to investigate the role of hydrogel charge and lower critical solution temperature over time in influencing cell proliferation and tissue integration. When compared to the positive and neutral gels of the same thermogelling polymer formulation due to increased transport and diffusion across the hydrogel-u2010tissue interface, Negatively charged hydrogels whose LCST increased over time were shown to promote the highest tissue integration. The negatively charged thermogelling polymer groups, which contained 5 and 10 mol% DBA, demonstrated cellular infiltration and cartilage deposition by histology. This research reveals the critical role that material physicochemical properties play in dictating cell and tissue function, as well as future cartilage tissue engineering methods.

Source link: https://onlinelibrary.wiley.com/doi/10.1002/jbm.a.37441

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions