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Cartilage - Springer Nature

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Last Updated: 10 January 2023

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Exploring the differences between radiographic joint space width and MRI cartilage thickness changes using data from the IMI-APPROACH cohort

Methods The new study included 178 people with medial osteoarthritis out of the 297 knee osteoarthritis patients enrolled in the IMI-APPROACH study. Changes in median JSW, minimum JSW, and medial femorotibial cartilage thickness were determined using linear regression, using radiographs and MRI results from baseline, 6 months, and 1 and 2 years ago. The results Correlations between u0394MFTC and u0394JSW were statistically significant but poor. Correlations were highly different between groups based on cartilage quality and on meniscal extrusion: only patients with the lowest T2 levels and with meniscal extrusion showed significant modest correlations. Conclusions Although the amount of load doesn't seem to matter, weight-bearing radiographic JSW results are a more accurate representation of non-weight-bearing MRI cartilage thickness changes in knees with increased quality cartilage and meniscal extrusion, according to the presenter.

Source link: https://doi.org/10.1007/s00256-022-04259-3


New refinements aim to optimize articular cartilage tissue engineering

For the prevention of osteoarthritis prevention, successful, long-term care of articular cartilage injuries, it's critical, but it's still a big challenge. In vivo, a synthetic artificial stem cell culture, engineered to mimic mesenchymal stem cells' secretome, attenuated cartilage degeneration and enhanced articular cartilage adhesive strength.

Source link: https://doi.org/10.1038/s41584-022-00889-y


Particulate cartilage and platelet-rich plasma treatment for knee chondral defects in sheep

The present research, therefore, sought to determine the chondrogenic regenerative capabilities of an autologous-made matrix of particulated cartilage and platelet-rich plasma implantation for the treatment of full-thickness chondral defects in sheep. Both knees of 16 sheep were found to have a full-thickness 8 mm diameter cartilage defect in the medial femoral condyle's weight-bearing region. The right knees of all animals were treated with particulated autograft cartilage implantation and platelet-rich plasma, while the left knees were injected with Ringeru2019s lactate solution or hyaluronic acid, while the left knees were treated with Ringer'u2019's lactate solution or hyaluronic acid. Results at 18 months compared to 9 months, the PACI + PRP groups showed statistically significant differences in the percentage of defect repair and chondrocytes in the newly formed cartilage tissue at 18 months.

Source link: https://doi.org/10.1007/s00167-022-07295-7


Combining Diced Cartilage with Chondrocyte Spheroids in GelMA Hydrogel: An Animal Study in Diced Cartilage Grafting Technique

BACKGROUND: In augmentation rhinoplasty, the phenotype maintenance of diced cartilage is a significant factor that can reduce cartilage absorption rates. In phenotype maintenance, a novel strategy that mixed diced cartilage with chondrocyte spheroids in gelatin methacrylate hydrogel may have potentially good results, and it's worth investigating. METHODS: As the experimental group, the complicated grafts made by loading diced cartilage with chondrocyte spheroids into GelMA hydrogel were used, and the control group was used to construct diced cartilage in GelMA gelMA. In the experimental group, proteoglycans were remarkably better than those in the control group. CONCLUSION: The combination of diced cartilage and chondrocyte spheroids in GelMA hydrogel can significantly reduce cartilage extracellular matrix absorption, enhance phenotype maintenance during subcutaneous ectopic implantation, and establish inter-chondral links.

Source link: https://doi.org/10.1007/s13770-022-00499-5


Inhibition of fibroblast activation protein ameliorates cartilage matrix degradation and osteoarthritis progression

Fap is highly expressed in bone marrow stromal cells and functions as an osteogenic suppressor, and can be stifled by bone growth factor Osteolectin. Fap is also present in synovial fibroblasts and is highly associated with rheumatoid arthritis severity. Fap is significantly elevated in osteoarthritic synovium, according to this study, although Fap's genetic mutation or pharmacological inhibition of Fap significantly reduced posttraumatic OA in mice. We found that Fap degrades denatured type II collagen and Mmp13-cleaved native Col II, according to Mechanistically. Col II degradation and OA progression were both accelerated by the Intra-articular injection of rFap, which in turn accelerated Col II degradation and OA progression.

Source link: https://doi.org/10.1038/s41413-022-00243-8


The role of TGF-beta3 in cartilage development and osteoarthritis

A series of cell responses, including cell proliferation, migration, and differentiation, influence the whole life cycle of chondrocytes and mediates a complex of cellular responses, including cell differentiation, cell proliferation, migration, and differentiation. Since TGF-u03b23 is involved in maintaining the balance between chondrogenic differentiation and chondrocyte hypertrophy, cartilage formation is particularly important to cartilage formation. However, the biological basis of TGF-u03b23 involvement in cartilage growth and OA is not well understood. We systematically summarize recent findings in the field of TGF-u03b23 cartilage physiology and pathology, providing up-to-date recommendations for cartilage repair and preventive therapy in this article.

Source link: https://doi.org/10.1038/s41413-022-00239-4


Mimicked 2D Scaffolds in Articular Cartilage Surgery

The key components of articular cartilage surgery, hydrogel, and 3D scaffolds are the primary materials that play a role as structures, with appropriate ability to enhance tissue formation, particularly in deep defects with included bone. In this chapter, the idea of surgery with 2D scaffolds is introduced, as well as mimicked 2D scaffolds for cartilage surgery.

Source link: https://doi.org/10.1007/978-981-19-7830-2_12


Isolation of Chondrons from Hyaline Cartilage

The chondrocytes in native healthy hyaline cartilage are enclosed by a pericellular matrix with a distinctive structure and function in comparison to the hyaline cartilage extracellular matrix. A chondron is a chondron composed of the chondrocyte and its pericellular matrix. Chondrons have a high success in cartilage tissue engineering. chondrons can be isolated from hyaline cartilage for further use in this chapter.

Source link: https://doi.org/10.1007/978-1-0716-2839-3_3


A Mouse Model of Acute Cartilage Injury and Repair

We present a method to produce full-thickness cartilage defects in young DBA/1 mice that heal spontaneously, but in C57BL/6 mice of the same age or aged DBA/1 mice, we show how to restore them in young DBA/1 mice.

Source link: https://doi.org/10.1007/978-1-0716-2839-3_24


Mimicked Hydrogel Scaffolds for Articular Cartilage Surgery

Many patients suffer with cartilage tissue abnormalities, particularly due to age and trauma. Patients will suffer severe discomfort as a result of defective cartilage tissue repair during the bone process. In some instances, a tissue engineering scaffold is used as a substitute biomaterial to regenerate new tissue. To encourage tissue regeneration at the defect site, constructing suitable scaffolds that are similar to native tissue is vital.

Source link: https://doi.org/10.1007/978-981-19-7830-2_10

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions